| EcoR1 Capital, LLC | 7,880,094 | $382,027 |
| Point72 Asset Management, L.P. | 1,932,890 | $93,707 |
| BlackRock, Inc. | 1,734,430 | $84,085 |
| VANGUARD GROUP INC | 1,544,037 | $74,855 |
| TANG CAPITAL MANAGEMENT LLC | 1,332,087 | $64,580 |
| STATE STREET CORP | 1,053,474 | $51,072 |
| MORGAN STANLEY | 1,034,562 | $50,156 |
| Sanofi | 821,917 | $39,847 |
| MILLENNIUM MANAGEMENT LLC | 813,571 | $39,442 |
| Palo Alto Investors LP | 690,032 | $33,453 |
| D. E. Shaw & Co., Inc. | 670,288 | $32,496 |
| 683 Capital Management, LLC | 648,093 | $31,420 |
| First Light Asset Management, LLC | 646,238 | $31,330 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 559,744 | $27,136 |
| Woodline Partners LP | 501,023 | $24,290 |
| GEODE CAPITAL MANAGEMENT, LLC | 469,494 | $22,766 |
| Affinity Asset Advisors, LLC | 444,692 | $21,559 |
| GOLDMAN SACHS GROUP INC | 398,914 | $19,339 |
| TWO SIGMA ADVISERS, LP | 356,700 | $17,293 |
| Nuveen, LLC | 316,685 | $15,353 |
| FEDERATED HERMES, INC. | 299,416 | $14,516 |
| Sofinnova Investments, Inc. | 287,690 | $13,947 |
| TWO SIGMA INVESTMENTS, LP | 256,635 | $12,442 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 229,137 | $11,109 |
| Ensign Peak Advisors, Inc | 215,454 | $10,445 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 198,660 | $9,631 |
| NORTHERN TRUST CORP | 181,884 | $8,818 |
| BNP PARIBAS ARBITRAGE, SA | 164,823 | $7,991 |
| Squarepoint Ops LLC | 160,731 | $7,792 |
| Soleus Capital Management, L.P. | 135,000 | $6,545 |
| BANK OF AMERICA CORP /DE/ | 130,767 | $6,340 |
| Granahan Investment Management, LLC | 125,855 | $6,101 |
| Invesco Ltd. | 124,006 | $6,012 |
| Connor, Clark & Lunn Investment Management Ltd. | 122,476 | $5,938 |
| Eversept Partners, LP | 120,927 | $5,863 |
| Jump Financial, LLC | 120,217 | $5,828 |
| VICTORY CAPITAL MANAGEMENT INC | 110,583 | $5,361 |
| CITADEL ADVISORS LLC | 109,483 | $5,308 |
| Qube Research & Technologies Ltd | 108,965 | $5,283 |
| HighMark Wealth Management LLC | 94,050 | $4,560 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 93,732 | $4,544 |
| JANE STREET GROUP, LLC | 84,447 | $4,094 |
| ExodusPoint Capital Management, LP | 83,313 | $4,039 |
| RENAISSANCE TECHNOLOGIES LLC | 76,300 | $3,699 |
| CITIGROUP INC | 73,453 | $3,561 |
| HRT FINANCIAL LP | 70,130 | $3 |
| UBS Group AG | 70,032 | $3,395 |
| WELLINGTON MANAGEMENT GROUP LLP | 61,187 | $2,966 |
| BARCLAYS PLC | 59,654 | $2,892 |
| Trexquant Investment LP | 58,809 | $2,851 |
| Fisher Asset Management, LLC | 56,564 | $2,742 |
| Penserra Capital Management LLC | 56,352 | $3 |
| Bank of New York Mellon Corp | 55,345 | $2,683 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 55,088 | $2,671 |
| Moody Aldrich Partners LLC | 47,601 | $2,308 |
| Bleakley Financial Group, LLC | 43,547 | $2,111 |
| PDT Partners, LLC | 43,001 | $2,085 |
| CREDIT AGRICOLE S A | 40,000 | $1,939 |
| XTX Topco Ltd | 38,637 | $1,873 |
| Susquehanna Portfolio Strategies, LLC | 35,948 | $1,743 |
| Rafferty Asset Management, LLC | 35,310 | $1,712 |
| DCF Advisers, LLC | 35,250 | $1,709 |
| Y-Intercept (Hong Kong) Ltd | 33,101 | $1,605 |
| ALLIANCEBERNSTEIN L.P. | 30,520 | $1,480 |
| UBS ASSET MANAGEMENT AMERICAS INC | 30,508 | $1,479 |
| OSAIC HOLDINGS, INC. | 27,737 | $1,345 |
| Swiss National Bank | 27,600 | $1,338 |
| FMR LLC | 27,108 | $1,314 |
| AQR CAPITAL MANAGEMENT LLC | 26,309 | $1,275 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,005 | $1 |
| Campbell & CO Investment Adviser LLC | 25,368 | $1,230 |
| Headlands Technologies LLC | 25,278 | $1,225 |
| RHUMBLINE ADVISERS | 25,032 | $1,214 |
| Schonfeld Strategic Advisors LLC | 24,431 | $1,184 |
| Quadrature Capital Ltd | 24,280 | $1,177 |
| MACKENZIE FINANCIAL CORP | 24,228 | $1,166 |
| NEOS Investment Management LLC | 22,895 | $1,110 |
| TEMA ETFS LLC | 22,560 | $1,094 |
| WELLS FARGO & COMPANY/MN | 22,207 | $1,077 |
| PANAGORA ASSET MANAGEMENT INC | 20,872 | $1,012 |
| Russell Investments Group, Ltd. | 19,714 | $956 |
| Legal & General Group Plc | 18,180 | $881 |
| TUDOR INVESTMENT CORP ET AL | 17,305 | $839 |
| ALGERT GLOBAL LLC | 16,400 | $1 |
| Creative Planning | 15,254 | $740 |
| Cresset Asset Management, LLC | 15,121 | $733 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 15,101 | $551 |
| Brinker Capital Investments, LLC | 14,697 | $713 |
| DEUTSCHE BANK AG\ | 14,381 | $697 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,138 | $685 |
| PROFUND ADVISORS LLC | 13,088 | $635 |
| Voya Investment Management LLC | 12,760 | $619 |
| JPMORGAN CHASE & CO | 10,916 | $529 |
| Engineers Gate Manager LP | 10,880 | $527 |
| GSA CAPITAL PARTNERS LLP | 10,695 | $1 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,641 | $515 |
| SG Americas Securities, LLC | 10,428 | $1 |
| MetLife Investment Management, LLC | 10,327 | $501 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,286 | $450 |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,088 | $441 |
| 77 other institutions | 200,453 | $9,000 |