APELLIS PHARMACEUTICALS INC

Ticker: APLS CUSIP: 03753U106 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 449,676 Value ($000) $11,296 Avg Close $23.46 Range $18.75 - $30.48

Q3 2025

Shares 456,791 Value ($000) $10,337 Avg Close $23.32 Range $17.35 - $28.97

Q2 2025

Shares 251,069 Value ($000) $4,346 Avg Close $18.51 Range $16.10 - $23.77

Q4 2024

Shares 20,000 Value ($000) $638 Avg Close $30.07 Range $24.34 - $35.72

Q4 2023

Shares 33,086 Value ($000) $1,981 Avg Close $50.73 Range $36.31 - $66.30

Q3 2023

Shares 39,473 Value ($000) $1,502 Avg Close $43.93 Range $19.83 - $91.35

Q2 2023

Shares 527,811 Value ($000) $48,084 Avg Close $86.28 Range $73.80 - $94.75

Q1 2023

Shares 412,853 Value ($000) $27,232 Avg Close $57.70 Range $44.92 - $70.75

Q4 2022

Shares 12,898 Value ($000) $667 Avg Close $53.04 Range $42.15 - $66.80

Q3 2022

Shares 197,364 Value ($000) $13,480 Avg Close $59.17 Range $44.07 - $70.00

Q2 2022

Shares 4,570 Value ($000) $207 Avg Close $45.59 Range $33.32 - $60.20

Q1 2022

Shares 33,034 Value ($000) $1,678 Avg Close $44.15 Range $33.50 - $54.51

Q4 2021

Shares 37,890 Value ($000) $1,791 Avg Close $39.37 Range $30.17 - $50.31

Q3 2021

Shares 75,522 Value ($000) $2,489 Avg Close $56.19 Range $27.50 - $73.00

Q2 2021

Shares 245,029 Value ($000) $15,486 Avg Close $51.60 Range $40.53 - $66.07

Q1 2021

Shares 336,643 Value ($000) $14,445 Avg Close $47.32 Range $39.95 - $58.47

Q4 2020

Shares 414,062 Value ($000) $23,684 Avg Close $42.30 Range $29.80 - $58.03

Q3 2020

Shares 385,866 Value ($000) $11,642 Avg Close $29.88 Range $25.49 - $34.08

Q2 2020

Shares 531,761 Value ($000) $17,367 Avg Close $32.11 Range $24.34 - $39.98

Q1 2020

Shares 369,733 Value ($000) $9,905 Avg Close $35.50 Range $16.85 - $45.04

Q4 2019

Shares 148,407 Value ($000) $4,544 Avg Close $27.68 Range $21.79 - $31.47

Q3 2019

Shares 11,065 Value ($000) $267 Avg Close $27.52 Range $23.83 - $33.18

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	449,676	$11,296	$23.46	$18.75 - $30.48
Q3 2025	456,791	$10,337	$23.32	$17.35 - $28.97
Q2 2025	251,069	$4,346	$18.51	$16.10 - $23.77
Q4 2024	20,000	$638	$30.07	$24.34 - $35.72
Q4 2023	33,086	$1,981	$50.73	$36.31 - $66.30
Q3 2023	39,473	$1,502	$43.93	$19.83 - $91.35
Q2 2023	527,811	$48,084	$86.28	$73.80 - $94.75
Q1 2023	412,853	$27,232	$57.70	$44.92 - $70.75
Q4 2022	12,898	$667	$53.04	$42.15 - $66.80
Q3 2022	197,364	$13,480	$59.17	$44.07 - $70.00
Q2 2022	4,570	$207	$45.59	$33.32 - $60.20
Q1 2022	33,034	$1,678	$44.15	$33.50 - $54.51
Q4 2021	37,890	$1,791	$39.37	$30.17 - $50.31
Q3 2021	75,522	$2,489	$56.19	$27.50 - $73.00
Q2 2021	245,029	$15,486	$51.60	$40.53 - $66.07
Q1 2021	336,643	$14,445	$47.32	$39.95 - $58.47
Q4 2020	414,062	$23,684	$42.30	$29.80 - $58.03
Q3 2020	385,866	$11,642	$29.88	$25.49 - $34.08
Q2 2020	531,761	$17,367	$32.11	$24.34 - $39.98
Q1 2020	369,733	$9,905	$35.50	$16.85 - $45.04
Q4 2019	148,407	$4,544	$27.68	$21.79 - $31.47
Q3 2019	11,065	$267	$27.52	$23.83 - $33.18