| WELLINGTON MANAGEMENT GROUP LLP | 12,721,352 | $319,560 |
| Avoro Capital Advisors LLC | 12,222,222 | $307,022 |
| VANGUARD GROUP INC | 10,674,865 | $268,153 |
| MORGAN STANLEY | 9,173,004 | $230,426 |
| Deep Track Capital, LP | 7,750,000 | $194,680 |
| RTW INVESTMENTS, LP | 7,666,764 | $192,589 |
| BlackRock, Inc. | 6,260,113 | $157,254 |
| STATE STREET CORP | 4,613,446 | $115,890 |
| UBS Group AG | 4,186,222 | $105,158 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,139,426 | $103,982 |
| Polar Capital Holdings Plc | 3,706,510 | $93,108 |
| Siren, L.L.C. | 2,578,396 | $64,769 |
| ORBIMED ADVISORS LLC | 2,429,868 | $61,038 |
| AQR CAPITAL MANAGEMENT LLC | 2,276,687 | $57,190 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,025,669 | $50,896 |
| JENNISON ASSOCIATES LLC | 1,504,299 | $37,788 |
| DEUTSCHE BANK AG\ | 1,385,263 | $34,798 |
| NORGES BANK | 1,198,444 | $30,105 |
| Hudson Bay Capital Management LP | 1,179,828 | $29,637 |
| BANK OF NOVA SCOTIA | 1,070,141 | $26,882 |
| MARSHALL WACE, LLP | 990,848 | $24,890 |
| BANK OF AMERICA CORP /DE/ | 956,773 | $24,034 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 951,716 | $19,729 |
| MILLENNIUM MANAGEMENT LLC | 946,459 | $23,775 |
| Kynam Capital Management, LP | 908,607 | $22,824 |
| NORTHERN TRUST CORP | 696,521 | $17,497 |
| Nuveen, LLC | 681,819 | $17,127 |
| CITADEL ADVISORS LLC | 648,229 | $16,284 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 644,445 | $16,188 |
| RENAISSANCE TECHNOLOGIES LLC | 633,058 | $15,902 |
| CITIGROUP INC | 622,158 | $15,629 |
| Point72 Asset Management, L.P. | 597,672 | $15,014 |
| AMERIPRISE FINANCIAL INC | 589,597 | $14,811 |
| SG Americas Securities, LLC | 567,046 | $14 |
| TWO SIGMA INVESTMENTS, LP | 562,361 | $14,127 |
| BNP PARIBAS ARBITRAGE, SA | 557,591 | $14,007 |
| Woodline Partners LP | 542,981 | $13,640 |
| Simplify Asset Management Inc. | 538,008 | $13,515 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 533,909 | $13,412 |
| FIRST TRUST ADVISORS LP | 495,947 | $12,458 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 461,186 | $11,585 |
| D. E. Shaw & Co., Inc. | 449,676 | $11,296 |
| OSSIAM | 431,779 | $10,846 |
| Pictet Asset Management Holding SA | 390,884 | $9,838 |
| Rhenman & Partners Asset Management AB | 374,450 | $9,406 |
| 683 Capital Management, LLC | 330,000 | $8,290 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 329,134 | $8,307 |
| Granite Investment Partners, LLC | 327,094 | $8,217 |
| J. Goldman & Co LP | 285,992 | $7,184 |
| Bank of New York Mellon Corp | 271,925 | $6,831 |
| NATIXIS | 257,268 | $6,463 |
| Caption Management, LLC | 254,563 | $6,395 |
| SPHERA FUNDS MANAGEMENT LTD. | 250,961 | $6,304 |
| JANUS HENDERSON GROUP PLC | 230,320 | $5,786 |
| Invesco Ltd. | 225,976 | $5,677 |
| CANADA PENSION PLAN INVESTMENT BOARD | 222,200 | $5,582 |
| TUDOR INVESTMENT CORP ET AL | 215,000 | $5,401 |
| ACADIAN ASSET MANAGEMENT LLC | 205,986 | $5 |
| Integral Health Asset Management, LLC | 200,000 | $5,024 |
| Trexquant Investment LP | 194,592 | $4,888 |
| Jump Financial, LLC | 193,876 | $4,870 |
| HRT FINANCIAL LP | 192,488 | $5 |
| Squarepoint Ops LLC | 192,156 | $4,827 |
| APIS CAPITAL ADVISORS, LLC | 192,000 | $4,823 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 190,759 | $4,792 |
| GOLDMAN SACHS GROUP INC | 189,205 | $4,753 |
| BARCLAYS PLC | 187,712 | $4,715 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 186,328 | $4,681 |
| DIMENSIONAL FUND ADVISORS LP | 180,925 | $4,545 |
| Fiduciary Trust Co | 180,254 | $4,528 |
| UBS ASSET MANAGEMENT AMERICAS INC | 178,888 | $4,494 |
| BANK OF MONTREAL /CAN/ | 176,571 | $4,435 |
| Rafferty Asset Management, LLC | 171,456 | $4,307 |
| ExodusPoint Capital Management, LP | 171,156 | $4,299 |
| Gotham Asset Management, LLC | 168,455 | $4,232 |
| JPMORGAN CHASE & CO | 157,754 | $3,963 |
| HighVista Strategies LLC | 150,776 | $3,787 |
| Rock Springs Capital Management LP | 150,500 | $3,781 |
| Swiss National Bank | 149,500 | $3,755 |
| Man Group plc | 144,271 | $3,624 |
| Bridgewater Associates, LP | 143,805 | $3,612 |
| ING GROEP NV | 139,000 | $3,492 |
| Exome Asset Management LLC | 135,849 | $3,413 |
| RHUMBLINE ADVISERS | 116,917 | $2,937 |
| TWO SIGMA ADVISERS, LP | 110,900 | $2,786 |
| ALGERT GLOBAL LLC | 109,733 | $3 |
| NEW YORK STATE COMMON RETIREMENT FUND | 104,018 | $2,613 |
| WELLS FARGO & COMPANY/MN | 103,815 | $2,608 |
| ALPS ADVISORS INC | 103,696 | $2,605 |
| Edgestream Partners, L.P. | 97,443 | $2,448 |
| MACKENZIE FINANCIAL CORP | 96,211 | $2,424 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 96,125 | $2,415 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 95,755 | $2,405 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 95,035 | $2 |
| ROYAL BANK OF CANADA | 88,687 | $2,228 |
| WINTON GROUP Ltd | 86,653 | $2,177 |
| Legal & General Group Plc | 85,489 | $2,147 |
| Steward Partners Investment Advisory, LLC | 81,698 | $2,052 |
| Coppell Advisory Solutions LLC | 77,390 | $1,953 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 73,203 | $1,839 |
| 177 other institutions | 2,508,705 | $57,501 |