APELLIS PHARMACEUTICALS INC

Ticker: APLS CUSIP: 03753U106 Class: Common Stock

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q2 2021

Shares 2,271,917 Value ($000) $143,585 Avg Close $51.60 Range $40.53 - $66.07

Q1 2021

Shares 1,674,004 Value ($000) $71,832 Avg Close $47.32 Range $39.95 - $58.47

Q4 2020

Shares 896,551 Value ($000) $51,283 Avg Close $42.30 Range $29.80 - $58.03

Q3 2020

Shares 896,551 Value ($000) $27,049 Avg Close $29.88 Range $25.49 - $34.08

Q2 2020

Shares 896,551 Value ($000) $29,281 Avg Close $32.11 Range $24.34 - $39.98

Q1 2020

Shares 896,551 Value ($000) $24,019 Avg Close $35.50 Range $16.85 - $45.04

Q4 2019

Shares 496,969 Value ($000) $15,217 Avg Close $27.68 Range $21.79 - $31.47

Q3 2019

Shares 313,725 Value ($000) $7,558 Avg Close $27.52 Range $23.83 - $33.18

Q2 2019

Shares 313,725 Value ($000) $7,950 Avg Close $20.35 Range $17.36 - $25.41

Q1 2019

Shares 313,725 Value ($000) $6,118 Avg Close $15.73 Range $12.50 - $20.03

Q4 2018

Shares 196,078 Value ($000) $2,586 Avg Close $15.34 Range $11.45 - $20.54

Q3 2018

Shares 196,078 Value ($000) $3,486 Avg Close $18.48 Range $16.25 - $21.93

Q2 2018

Shares 196,078 Value ($000) $4,314 Avg Close $22.98 Range $18.89 - $32.00

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2021	2,271,917	$143,585	$51.60	$40.53 - $66.07
Q1 2021	1,674,004	$71,832	$47.32	$39.95 - $58.47
Q4 2020	896,551	$51,283	$42.30	$29.80 - $58.03
Q3 2020	896,551	$27,049	$29.88	$25.49 - $34.08
Q2 2020	896,551	$29,281	$32.11	$24.34 - $39.98
Q1 2020	896,551	$24,019	$35.50	$16.85 - $45.04
Q4 2019	496,969	$15,217	$27.68	$21.79 - $31.47
Q3 2019	313,725	$7,558	$27.52	$23.83 - $33.18
Q2 2019	313,725	$7,950	$20.35	$17.36 - $25.41
Q1 2019	313,725	$6,118	$15.73	$12.50 - $20.03
Q4 2018	196,078	$2,586	$15.34	$11.45 - $20.54
Q3 2018	196,078	$3,486	$18.48	$16.25 - $21.93
Q2 2018	196,078	$4,314	$22.98	$18.89 - $32.00