APELLIS PHARMACEUTICALS INC

Ticker: APLS CUSIP: 03753U106 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 110,900 Value ($000) $2,786 Avg Close $23.46 Range $18.75 - $30.48

Q2 2025

Shares 256,800 Value ($000) $4,445 Avg Close $18.51 Range $16.10 - $23.77

Q1 2025

Shares 191,800 Value ($000) $4,195 Avg Close $27.62 Range $21.70 - $35.57

Q4 2021

Shares 30,600 Value ($000) $1,447 Avg Close $39.37 Range $30.17 - $50.31

Q3 2021

Shares 491,600 Value ($000) $16,203 Avg Close $56.19 Range $27.50 - $73.00

Q2 2021

Shares 623,900 Value ($000) $39,430 Avg Close $51.60 Range $40.53 - $66.07

Q1 2021

Shares 687,400 Value ($000) $29,496 Avg Close $47.32 Range $39.95 - $58.47

Q4 2020

Shares 708,600 Value ($000) $40,532 Avg Close $42.30 Range $29.80 - $58.03

Q3 2020

Shares 812,200 Value ($000) $24,504 Avg Close $29.88 Range $25.49 - $34.08

Q2 2020

Shares 921,200 Value ($000) $30,086 Avg Close $32.11 Range $24.34 - $39.98

Q1 2020

Shares 877,200 Value ($000) $23,500 Avg Close $35.50 Range $16.85 - $45.04

Q4 2019

Shares 260,000 Value ($000) $7,961 Avg Close $27.68 Range $21.79 - $31.47

Q3 2019

Shares 70,700 Value ($000) $1,703 Avg Close $27.52 Range $23.83 - $33.18

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	110,900	$2,786	$23.46	$18.75 - $30.48
Q2 2025	256,800	$4,445	$18.51	$16.10 - $23.77
Q1 2025	191,800	$4,195	$27.62	$21.70 - $35.57
Q4 2021	30,600	$1,447	$39.37	$30.17 - $50.31
Q3 2021	491,600	$16,203	$56.19	$27.50 - $73.00
Q2 2021	623,900	$39,430	$51.60	$40.53 - $66.07
Q1 2021	687,400	$29,496	$47.32	$39.95 - $58.47
Q4 2020	708,600	$40,532	$42.30	$29.80 - $58.03
Q3 2020	812,200	$24,504	$29.88	$25.49 - $34.08
Q2 2020	921,200	$30,086	$32.11	$24.34 - $39.98
Q1 2020	877,200	$23,500	$35.50	$16.85 - $45.04
Q4 2019	260,000	$7,961	$27.68	$21.79 - $31.47
Q3 2019	70,700	$1,703	$27.52	$23.83 - $33.18