APELLIS PHARMACEUTICALS INC

Ticker: APLS CUSIP: 03753U106 Class: Common Stock

Rhenman & Partners Asset Management AB's Holding History (CIK: 0001599882)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 374,450 Value ($000) $9,406 Avg Close $23.46 Range $18.75 - $30.48

Q3 2025

Shares 232,250 Value ($000) $5,256 Avg Close $23.32 Range $17.35 - $28.97

Q2 2025

Shares 93,250 Value ($000) $1,614 Avg Close $18.51 Range $16.10 - $23.77

Q1 2025

Shares 28,250 Value ($000) $618 Avg Close $27.62 Range $21.70 - $35.57

Q4 2024

Shares 195,591 Value ($000) $6,241 Avg Close $30.07 Range $24.34 - $35.72

Q3 2024

Shares 367,500 Value ($000) $10,599 Avg Close $37.03 Range $28.32 - $42.47

Q2 2024

Shares 55,395 Value ($000) $2,125 Avg Close $45.29 Range $37.00 - $59.91

Q1 2024

Shares 178,395 Value ($000) $10,486 Avg Close $63.75 Range $53.19 - $73.80

Q4 2023

Shares 100,400 Value ($000) $6,010 Avg Close $50.73 Range $36.31 - $66.30

Q3 2023

Shares 215,000 Value ($000) $8,179 Avg Close $43.93 Range $19.83 - $91.35

Q2 2023

Shares 190,000 Value ($000) $17,309 Avg Close $86.28 Range $73.80 - $94.75

Q1 2023

Shares 185,000 Value ($000) $12,214 Avg Close $57.70 Range $44.92 - $70.75

Q4 2022

Shares 200,000 Value ($000) $10,342 Avg Close $53.04 Range $42.15 - $66.80

Q3 2022

Shares 220,000 Value ($000) $13,308 Avg Close $59.17 Range $44.07 - $70.00

Q2 2022

Shares 210,000 Value ($000) $9,496 Avg Close $45.59 Range $33.32 - $60.20

Q1 2022

Shares 377,000 Value ($000) $19,155 Avg Close $44.15 Range $33.50 - $54.51

Q4 2021

Shares 430,000 Value ($000) $20,619 Avg Close $39.37 Range $30.17 - $50.31

Q3 2021

Shares 561,269 Value ($000) $18,499 Avg Close $56.19 Range $27.50 - $73.00

Q2 2021

Shares 305,000 Value ($000) $19,276 Avg Close $51.60 Range $40.53 - $66.07

Q1 2021

Shares 270,000 Value ($000) $11,586 Avg Close $47.32 Range $39.95 - $58.47

Q4 2020

Shares 270,000 Value ($000) $15,444 Avg Close $42.30 Range $29.80 - $58.03

Q3 2020

Shares 225,000 Value ($000) $6,788 Avg Close $29.88 Range $25.49 - $34.08

Q2 2020

Shares 165,000 Value ($000) $5,389 Avg Close $32.11 Range $24.34 - $39.98

Q1 2020

Shares 100,000 Value ($000) $2,679 Avg Close $35.50 Range $16.85 - $45.04

Q4 2019

Shares 80,000 Value ($000) $2,450 Avg Close $27.68 Range $21.79 - $31.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	374,450	$9,406	$23.46	$18.75 - $30.48
Q3 2025	232,250	$5,256	$23.32	$17.35 - $28.97
Q2 2025	93,250	$1,614	$18.51	$16.10 - $23.77
Q1 2025	28,250	$618	$27.62	$21.70 - $35.57
Q4 2024	195,591	$6,241	$30.07	$24.34 - $35.72
Q3 2024	367,500	$10,599	$37.03	$28.32 - $42.47
Q2 2024	55,395	$2,125	$45.29	$37.00 - $59.91
Q1 2024	178,395	$10,486	$63.75	$53.19 - $73.80
Q4 2023	100,400	$6,010	$50.73	$36.31 - $66.30
Q3 2023	215,000	$8,179	$43.93	$19.83 - $91.35
Q2 2023	190,000	$17,309	$86.28	$73.80 - $94.75
Q1 2023	185,000	$12,214	$57.70	$44.92 - $70.75
Q4 2022	200,000	$10,342	$53.04	$42.15 - $66.80
Q3 2022	220,000	$13,308	$59.17	$44.07 - $70.00
Q2 2022	210,000	$9,496	$45.59	$33.32 - $60.20
Q1 2022	377,000	$19,155	$44.15	$33.50 - $54.51
Q4 2021	430,000	$20,619	$39.37	$30.17 - $50.31
Q3 2021	561,269	$18,499	$56.19	$27.50 - $73.00
Q2 2021	305,000	$19,276	$51.60	$40.53 - $66.07
Q1 2021	270,000	$11,586	$47.32	$39.95 - $58.47
Q4 2020	270,000	$15,444	$42.30	$29.80 - $58.03
Q3 2020	225,000	$6,788	$29.88	$25.49 - $34.08
Q2 2020	165,000	$5,389	$32.11	$24.34 - $39.98
Q1 2020	100,000	$2,679	$35.50	$16.85 - $45.04
Q4 2019	80,000	$2,450	$27.68	$21.79 - $31.47