APOGEE THERAPEUTICS INC

Ticker: APGE CUSIP: 03770N101 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 105,241 Value ($000) $7,944 Avg Close $62.99 Range $38.88 - $80.99

Q3 2025

Shares 122,375 Value ($000) $4,862 Avg Close $38.18 Range $34.34 - $47.71

Q2 2025

Shares 115,694 Value ($000) $5,025 Avg Close $38.04 Range $26.20 - $44.65

Q1 2025

Shares 252,135 Value ($000) $9,420 Avg Close $38.66 Range $29.10 - $50.56

Q4 2024

Shares 266,482 Value ($000) $12,072 Avg Close $51.00 Range $41.85 - $63.50

Q3 2024

Shares 199,308 Value ($000) $11,707 Avg Close $47.91 Range $36.60 - $60.82

Q2 2024

Shares 302,222 Value ($000) $11,892 Avg Close $48.54 Range $36.26 - $68.21

Q1 2024

Shares 89,480 Value ($000) $5,946 Avg Close $43.66 Range $27.05 - $72.29

Q4 2023

Shares 25,039 Value ($000) $700 Avg Close $20.05 Range $14.19 - $33.08

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	105,241	$7,944	$62.99	$38.88 - $80.99
Q3 2025	122,375	$4,862	$38.18	$34.34 - $47.71
Q2 2025	115,694	$5,025	$38.04	$26.20 - $44.65
Q1 2025	252,135	$9,420	$38.66	$29.10 - $50.56
Q4 2024	266,482	$12,072	$51.00	$41.85 - $63.50
Q3 2024	199,308	$11,707	$47.91	$36.60 - $60.82
Q2 2024	302,222	$11,892	$48.54	$36.26 - $68.21
Q1 2024	89,480	$5,946	$43.66	$27.05 - $72.29
Q4 2023	25,039	$700	$20.05	$14.19 - $33.08