| VR Adviser, LLC | 8,493,321 | $641,076 |
| FMR LLC | 8,225,038 | $620,826 |
| WELLINGTON MANAGEMENT GROUP LLP | 4,746,585 | $358,272 |
| BlackRock, Inc. | 3,783,994 | $285,616 |
| VANGUARD GROUP INC | 2,857,824 | $215,709 |
| RTW INVESTMENTS, LP | 2,712,097 | $204,709 |
| PERCEPTIVE ADVISORS LLC | 2,330,651 | $175,918 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,183,704 | $164,826 |
| JANUS HENDERSON GROUP PLC | 2,062,604 | $155,697 |
| Fairmount Funds Management LLC | 2,048,647 | $154,632 |
| STATE STREET CORP | 1,690,186 | $127,575 |
| T. Rowe Price Investment Management, Inc. | 1,555,987 | $117 |
| JPMORGAN CHASE & CO | 1,373,066 | $103,639 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,237,135 | $93 |
| Affinity Asset Advisors, LLC | 1,234,926 | $93,212 |
| Paradigm Biocapital Advisors LP | 1,123,243 | $84,782 |
| ALLIANCEBERNSTEIN L.P. | 1,093,657 | $82,549 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,059,085 | $79,957 |
| UBS Group AG | 974,826 | $73,580 |
| MERCER GLOBAL ADVISORS INC /ADV | 890,665 | $67,227 |
| MORGAN STANLEY | 890,264 | $67,197 |
| BANK OF AMERICA CORP /DE/ | 793,695 | $59,908 |
| CITADEL ADVISORS LLC | 766,981 | $57,892 |
| Remedium Capital Partners, LLC | 583,591 | $44 |
| JENNISON ASSOCIATES LLC | 578,627 | $43,675 |
| BRAIDWELL LP | 575,067 | $43,406 |
| Novo Holdings A/S | 570,000 | $43,024 |
| GOLDMAN SACHS GROUP INC | 565,410 | $42,677 |
| Vestal Point Capital, LP | 550,000 | $41,514 |
| Sofinnova Investments, Inc. | 534,845 | $40,370 |
| Polar Capital Holdings Plc | 503,539 | $38,007 |
| Avoro Capital Advisors LLC | 500,000 | $37,740 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 480,453 | $36,265 |
| First Turn Management, LLC | 474,839 | $35,841 |
| FRANKLIN RESOURCES INC | 451,002 | $34,042 |
| EVENTIDE ASSET MANAGEMENT, LLC | 436,015 | $32,910 |
| Opaleye Management Inc. | 388,257 | $29,306 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 381,362 | $28,785 |
| GREAT POINT PARTNERS LLC | 374,000 | $28,230 |
| NORTHERN TRUST CORP | 327,376 | $24,710 |
| Pictet Asset Management Holding SA | 312,883 | $23,616 |
| First Light Asset Management, LLC | 284,991 | $21,511 |
| LOOMIS SAYLES & CO L P | 255,439 | $19,281 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 240,000 | $18,115 |
| Woodline Partners LP | 210,466 | $15,886 |
| Trails Edge Capital Partners, LP | 192,000 | $14,492 |
| Candriam S.C.A. | 191,318 | $14,441 |
| MILLENNIUM MANAGEMENT LLC | 140,727 | $10,622 |
| BARCLAYS PLC | 133,193 | $10,053 |
| Parkman Healthcare Partners LLC | 130,069 | $9,818 |
| TD Asset Management Inc | 129,290 | $9,759 |
| FEDERATED HERMES, INC. | 127,931 | $9,656 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 127,629 | $9,633 |
| Capital World Investors | 127,618 | $9,633 |
| KENNEDY CAPITAL MANAGEMENT LLC | 124,979 | $9,433 |
| AMERIPRISE FINANCIAL INC | 122,900 | $9,276 |
| Nuveen, LLC | 121,050 | $9,137 |
| Bank of New York Mellon Corp | 118,084 | $8,913 |
| Nicholas Investment Partners, LP | 112,924 | $8,524 |
| ArrowMark Colorado Holdings LLC | 109,410 | $8,258 |
| VICTORY CAPITAL MANAGEMENT INC | 108,267 | $8,172 |
| TWO SIGMA INVESTMENTS, LP | 105,241 | $7,944 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 105,000 | $7,955 |
| NEUBERGER BERMAN GROUP LLC | 99,648 | $7,521 |
| Granahan Investment Management, LLC | 94,720 | $7,149 |
| HighVista Strategies LLC | 89,229 | $6,735 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 80,832 | $6,118 |
| STEMPOINT CAPITAL LP | 80,574 | $6,082 |
| DEUTSCHE BANK AG\ | 79,361 | $5,990 |
| NOMURA HOLDINGS INC | 76,898 | $5,804 |
| SG Americas Securities, LLC | 73,262 | $6 |
| Invesco Ltd. | 70,687 | $5,335 |
| Boxer Capital Management, LLC | 70,000 | $5,284 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 69,212 | $5,224 |
| D. E. Shaw & Co., Inc. | 63,250 | $4,774 |
| Swiss National Bank | 62,900 | $4,748 |
| SIMPLEX TRADING, LLC | 62,799 | $4,740 |
| PRUDENTIAL FINANCIAL INC | 54,300 | $4,099 |
| Blackstone Inc. | 51,827 | $3,912 |
| MARSHALL WACE, LLP | 50,744 | $3,830 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $3,774 |
| Russell Investments Group, Ltd. | 49,999 | $3,774 |
| UBS ASSET MANAGEMENT AMERICAS INC | 49,805 | $3,759 |
| Rafferty Asset Management, LLC | 48,619 | $3,670 |
| RHUMBLINE ADVISERS | 45,971 | $3,470 |
| ALPS ADVISORS INC | 44,922 | $3,391 |
| WELLS FARGO & COMPANY/MN | 42,499 | $3,208 |
| BANQUE PICTET & CIE SA | 41,800 | $3,155 |
| BNP Paribas Investment Partners S.A. | 39,846 | $3 |
| abrdn plc | 36,103 | $2,725 |
| COMERICA BANK | 35,872 | $2,708 |
| Cinctive Capital Management LP | 33,264 | $2,511 |
| Legal & General Group Plc | 32,856 | $2,480 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,758 | $2,322 |
| TUDOR INVESTMENT CORP ET AL | 30,039 | $2,267 |
| Schonfeld Strategic Advisors LLC | 29,145 | $2,200 |
| Erste Asset Management GmbH | 24,000 | $1,833 |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,484 | $1,697 |
| MetLife Investment Management, LLC | 21,311 | $1,609 |
| SummitTX Capital, L.P. | 20,972 | $1,583 |
| 106 other institutions | 586,834 | $41,935 |