APPLIED THERAPEUTICS INC

CUSIP: 03828A101 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025
Shares 198,933 Value ($000) $120 Avg Close — Range —
Q2 2025
Shares 594,534 Value ($000) $185 Avg Close — Range —
Q1 2025
Shares 960,587 Value ($000) $470 Avg Close — Range —
Q4 2024
Shares 293,810 Value ($000) $252 Avg Close — Range —
Q2 2024
Shares 43,338 Value ($000) $202 Avg Close — Range —
Q1 2024
Shares 155,158 Value ($000) $1,055 Avg Close — Range —
Q4 2023
Shares 285,997 Value ($000) $958 Avg Close — Range —
Q3 2023
Shares 69,351 Value ($000) $173 Avg Close — Range —
Q2 2023
Shares 24,554 Value ($000) $31 Avg Close — Range —
Q1 2023
Shares 89,149 Value ($000) $72 Avg Close — Range —
Q4 2022
Shares 177,773 Value ($000) $135 Avg Close — Range —
Q3 2022
Shares 181,601 Value ($000) $169 Avg Close — Range —
Q2 2022
Shares 178,251 Value ($000) $169 Avg Close — Range —
Q1 2022
Shares 280,273 Value ($000) $591 Avg Close — Range —
Q4 2021
Shares 28,431 Value ($000) $254 Avg Close — Range —
Q3 2021
Shares 29,134 Value ($000) $484 Avg Close — Range —
Q2 2021
Shares 10,491 Value ($000) $218 Avg Close — Range —
Q3 2020
Shares 27,363 Value ($000) $568 Avg Close — Range —
Q1 2020
Shares 7,834 Value ($000) $256 Avg Close — Range —