APPLIED THERAPEUTICS INC

CUSIP: 03828A101 Class: Common Stock

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
T. Rowe Price Investment Management, Inc.8,344,483$1
VANGUARD GROUP INC6,353,018$635
Knoll Capital Management, LLC6,050,000$605
DELTEC ASSET MANAGEMENT LLC3,847,449$385
BlackRock, Inc.3,251,462$325
RENAISSANCE TECHNOLOGIES LLC2,706,156$271
Pathstone Holdings, LLC2,643,540$305
JANE STREET GROUP, LLC2,087,404$209
GEODE CAPITAL MANAGEMENT, LLC1,492,903$149
ADAGE CAPITAL PARTNERS GP, L.L.C.1,211,629$121
MILLENNIUM MANAGEMENT LLC1,051,846$105
UBS Group AG718,924$72
DEUTSCHE BANK AG\622,226$62
Graham Capital Management, L.P.572,759$57
STATE STREET CORP558,178$56
Virtu Financial LLC496,288$0
Lynx1 Capital Management LP410,500$41
MARSHALL WACE, LLP337,389$34
Hennion & Walsh Asset Management, Inc.327,137$33
EQUITEC PROPRIETARY MARKETS, LLC300,600$30
Bank of New York Mellon Corp253,575$25
NORTHERN TRUST CORP245,144$25
Rockefeller Capital Management L.P.241,897$24
GTS SECURITIES LLC200,009$20
MORGAN STANLEY178,474$18
CreativeOne Wealth, LLC169,974$17
CITIGROUP INC163,449$16
GOLDMAN SACHS GROUP INC146,219$15
Roble, Belko & Company, Inc65,571$0
TUDOR INVESTMENT CORP ET AL57,454$6
SUSQUEHANNA INTERNATIONAL GROUP, LLP52,692$5
SPHERA FUNDS MANAGEMENT LTD.50,000$5
GROUP ONE TRADING, L.P.48,675$5
SG Americas Securities, LLC41,748$0
Adams Wealth Management38,637$4
CacheTech Inc.38,637$4
Tower Research Capital LLC (TRC)19,675$2
Cresset Asset Management, LLC17,091$2
Point72 Asset Management, L.P.17,020$2
AQR CAPITAL MANAGEMENT LLC13,413$1
JPMORGAN CHASE & CO12,064$1
Perennial Investment Advisors, LLC11,600$1
AlphaQuest LLC4,661$0
BANK OF AMERICA CORP /DE/3,109$0
BNP PARIBAS ARBITRAGE, SA2,974$0
ROYAL BANK OF CANADA852$0
SBI Securities Co., Ltd.788$0
RHUMBLINE ADVISERS544$0
Optiver Holding B.V.427$0
FMR LLC184$0
Federation des caisses Desjardins du Quebec84$0
BARCLAYS PLC1$0
Total (52 institutions)45,480,533$3,695