APPLIED THERAPEUTICS INC

CUSIP: 03828A101 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q2 2025
Shares 303,900 Value ($000) $95 Avg Close — Range —
Q1 2025
Shares 658,400 Value ($000) $322 Avg Close — Range —
Q4 2023
Shares 51,000 Value ($000) $171 Avg Close — Range —
Q3 2023
Shares 15,600 Value ($000) $39 Avg Close — Range —
Q2 2023
Shares 106,671 Value ($000) $137 Avg Close — Range —
Q1 2023
Shares 149,787 Value ($000) $121 Avg Close — Range —
Q4 2022
Shares 249,900 Value ($000) $190 Avg Close — Range —
Q3 2022
Shares 249,200 Value ($000) $232 Avg Close — Range —
Q2 2022
Shares 112,400 Value ($000) $107 Avg Close — Range —
Q1 2022
Shares 105,100 Value ($000) $222 Avg Close — Range —
Q4 2021
Shares 12,900 Value ($000) $115 Avg Close — Range —
Q3 2021
Shares 10,400 Value ($000) $173 Avg Close — Range —