ARDELYX INC

Ticker: ARDX CUSIP: 039697107 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 2,873,969 Value ($000) $16,755 Avg Close $5.57 Range $4.71 - $6.73

Q3 2025

Shares 2,490,848 Value ($000) $13,725 Avg Close $5.43 Range $3.80 - $6.78

Q2 2025

Shares 2,021,463 Value ($000) $7,924 Avg Close $4.13 Range $3.21 - $5.64

Q1 2025

Shares 1,010,138 Value ($000) $4,960 Avg Close $5.37 Range $4.67 - $6.55

Q4 2024

Shares 1,141,777 Value ($000) $5,789 Avg Close $5.52 Range $4.32 - $7.04

Q3 2024

Shares 984,361 Value ($000) $6,782 Avg Close $5.90 Range $5.07 - $8.06

Q2 2024

Shares 2,009,824 Value ($000) $14,893 Avg Close $7.03 Range $5.76 - $9.33

Q1 2024

Shares 2,561,896 Value ($000) $18,702 Avg Close $8.55 Range $5.92 - $10.13

Q4 2023

Shares 469,293 Value ($000) $2,910 Avg Close $4.49 Range $3.16 - $6.75

Q3 2023

Shares 423,740 Value ($000) $1,729 Avg Close $3.90 Range $3.26 - $4.97

Q2 2023

Shares 920,271 Value ($000) $3,120 Avg Close $4.10 Range $3.19 - $5.13

Q1 2023

Shares 2,845,385 Value ($000) $13,629 Avg Close $3.37 Range $2.63 - $4.94

Q4 2022

Shares 2,341,413 Value ($000) $6,673 Avg Close $1.69 Range $1.16 - $2.86

Q3 2021

Shares 850,970 Value ($000) $1,123 Avg Close $2.67 Range $1.25 - $8.25

Q2 2021

Shares 79,808 Value ($000) $605 Avg Close $7.39 Range $6.22 - $9.23

Q1 2021

Shares 674,373 Value ($000) $4,464 Avg Close $6.86 Range $5.91 - $7.86

Q4 2020

Shares 420,853 Value ($000) $2,723 Avg Close $5.93 Range $4.96 - $7.35

Q3 2020

Shares 485,045 Value ($000) $2,546 Avg Close $6.01 Range $5.21 - $7.19

Q2 2020

Shares 464,454 Value ($000) $3,214 Avg Close $6.95 Range $5.24 - $8.33

Q1 2020

Shares 170,530 Value ($000) $969 Avg Close $6.80 Range $4.22 - $8.81

Q4 2019

Shares 325,816 Value ($000) $2,445 Avg Close $6.08 Range $4.16 - $8.49

Q3 2019

Shares 246,370 Value ($000) $1,158 Avg Close $3.47 Range $2.10 - $6.78

Q2 2019

Shares 216,408 Value ($000) $582 Avg Close $3.01 Range $2.35 - $3.90

Q1 2019

Shares 229,704 Value ($000) $643 Avg Close $2.60 Range $1.70 - $3.45

Q4 2018

Shares 434,787 Value ($000) $778 Avg Close $2.94 Range $1.60 - $4.42

Q3 2018

Shares 507,384 Value ($000) $2,207 Avg Close $4.16 Range $3.58 - $4.70

Q2 2018

Shares 604,693 Value ($000) $2,237 Avg Close $4.64 Range $3.60 - $5.90

Q1 2018

Shares 18,200 Value ($000) $92 Avg Close $6.24 Range $5.01 - $8.10

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	2,873,969	$16,755	$5.57	$4.71 - $6.73
Q3 2025	2,490,848	$13,725	$5.43	$3.80 - $6.78
Q2 2025	2,021,463	$7,924	$4.13	$3.21 - $5.64
Q1 2025	1,010,138	$4,960	$5.37	$4.67 - $6.55
Q4 2024	1,141,777	$5,789	$5.52	$4.32 - $7.04
Q3 2024	984,361	$6,782	$5.90	$5.07 - $8.06
Q2 2024	2,009,824	$14,893	$7.03	$5.76 - $9.33
Q1 2024	2,561,896	$18,702	$8.55	$5.92 - $10.13
Q4 2023	469,293	$2,910	$4.49	$3.16 - $6.75
Q3 2023	423,740	$1,729	$3.90	$3.26 - $4.97
Q2 2023	920,271	$3,120	$4.10	$3.19 - $5.13
Q1 2023	2,845,385	$13,629	$3.37	$2.63 - $4.94
Q4 2022	2,341,413	$6,673	$1.69	$1.16 - $2.86
Q3 2021	850,970	$1,123	$2.67	$1.25 - $8.25
Q2 2021	79,808	$605	$7.39	$6.22 - $9.23
Q1 2021	674,373	$4,464	$6.86	$5.91 - $7.86
Q4 2020	420,853	$2,723	$5.93	$4.96 - $7.35
Q3 2020	485,045	$2,546	$6.01	$5.21 - $7.19
Q2 2020	464,454	$3,214	$6.95	$5.24 - $8.33
Q1 2020	170,530	$969	$6.80	$4.22 - $8.81
Q4 2019	325,816	$2,445	$6.08	$4.16 - $8.49
Q3 2019	246,370	$1,158	$3.47	$2.10 - $6.78
Q2 2019	216,408	$582	$3.01	$2.35 - $3.90
Q1 2019	229,704	$643	$2.60	$1.70 - $3.45
Q4 2018	434,787	$778	$2.94	$1.60 - $4.42
Q3 2018	507,384	$2,207	$4.16	$3.58 - $4.70
Q2 2018	604,693	$2,237	$4.64	$3.60 - $5.90
Q1 2018	18,200	$92	$6.24	$5.01 - $8.10