ARDELYX INC

Ticker: ARDX CUSIP: 039697107 Class: Common Stock

Note: Option positions (PUT/CALL) are excluded.

InstitutionSharesValue ($000)
BlackRock, Inc.21,139,105$123,241
VANGUARD GROUP INC18,979,483$110,650
JANUS HENDERSON GROUP PLC14,514,692$84,583
STATE STREET CORP11,912,339$69,449
MILLENNIUM MANAGEMENT LLC11,909,511$69,432
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.9,328,744$54,387
GEODE CAPITAL MANAGEMENT, LLC5,827,618$33,981
MARSHALL WACE, LLP5,188,639$30,250
Nuveen, LLC5,164,549$30,109
GOLDMAN SACHS GROUP INC3,064,746$17,867
TWO SIGMA INVESTMENTS, LP2,873,969$16,755
MORGAN STANLEY2,358,806$13,752
Rock Springs Capital Management LP2,299,473$13,406
BANK OF AMERICA CORP /DE/2,208,693$12,877
CHARLES SCHWAB INVESTMENT MANAGEMENT INC2,117,293$12,344
JANE STREET GROUP, LLC2,060,667$12,014
AQR CAPITAL MANAGEMENT LLC2,025,083$11,806
NORTHERN TRUST CORP2,019,285$11,772
ORACLE INVESTMENT MANAGEMENT INC1,872,624$10,917
JONES FINANCIAL COMPANIES LLLP1,854,755$10,813
RENAISSANCE TECHNOLOGIES LLC1,794,793$10,464
Eversept Partners, LP1,715,129$9,999
J. Goldman & Co LP1,622,736$9,461
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP1,424,878$8,307
D. E. Shaw & Co., Inc.1,411,267$8,228
TWO SIGMA ADVISERS, LP1,348,700$7,863
CITADEL ADVISORS LLC1,327,453$7,739
AIGH Capital Management LLC1,150,000$6,705
Qube Research & Technologies Ltd1,096,117$6,390
FIRST TRUST ADVISORS LP1,036,492$6,043
BNP PARIBAS ARBITRAGE, SA1,000,926$5,835
Hennion & Walsh Asset Management, Inc.959,540$5,594
Point72 Asset Management, L.P.958,690$5,589
SUSQUEHANNA INTERNATIONAL GROUP, LLP776,205$4,525
BARCLAYS PLC763,364$4,450
JPMORGAN CHASE & CO736,190$4,292
Bank of New York Mellon Corp723,158$4,216
Freestone Grove Partners LP699,133$4,076
FMR LLC677,436$3,949
PANAGORA ASSET MANAGEMENT INC659,160$3,843
UBS Group AG578,344$3,372
DEUTSCHE BANK AG\500,195$2,916
Y-Intercept (Hong Kong) Ltd499,668$2,913
Swiss National Bank475,200$2,770
UBS ASSET MANAGEMENT AMERICAS INC431,247$2,514
Rafferty Asset Management, LLC390,214$2,275
PRUDENTIAL FINANCIAL INC388,840$2,267
SCHRODER INVESTMENT MANAGEMENT GROUP368,448$2,137
Universal- Beteiligungs- und Servicegesellschaft mbH347,609$2,027
Squarepoint Ops LLC346,142$2,018
Trexquant Investment LP327,159$1,907
WELLS FARGO & COMPANY/MN318,413$1,856
Invesco Ltd.317,410$1,851
Clay Northam Wealth Management, LLC315,015$1,837
Pekin Hardy Strauss, Inc.305,230$1,779
RHUMBLINE ADVISERS297,924$1,737
CAPITAL FUND MANAGEMENT S.A.283,892$1,655
Raiffeisen Bank International AG270,000$1,566
Legal & General Group Plc268,263$1,564
ALLIANCEBERNSTEIN L.P.267,340$1,559
DIADEMA PARTNERS LP252,198$1,470
IEQ CAPITAL, LLC246,434$1,437
PRICE T ROWE ASSOCIATES INC /MD/234,466$1
Walleye Capital LLC221,308$1,290
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM217,662$1,269
MACKENZIE FINANCIAL CORP199,550$1,155
Jump Financial, LLC199,470$1,163
Headlands Technologies LLC199,280$1,162
STATE OF WISCONSIN INVESTMENT BOARD195,944$1,142
MONIMUS CAPITAL MANAGEMENT, LP194,734$1,135
RAYMOND JAMES FINANCIAL INC193,769$1,130
SG Americas Securities, LLC171,580$1
Thrivent Financial for Lutherans162,786$1
LPL Financial LLC159,932$932
FRANKLIN RESOURCES INC154,698$902
HARBOR CAPITAL ADVISORS, INC.153,825$1
GROUP ONE TRADING, L.P.153,811$897
SIMPLEX TRADING, LLC151,934$886
PROFUND ADVISORS LLC145,333$847
PFG Investments, LLC137,860$804
Engineers Gate Manager LP137,582$802
ALGERT GLOBAL LLC134,206$1
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.134,029$781
CANADA PENSION PLAN INVESTMENT BOARD131,900$769
Lion Point Capital, LP128,650$750
INTECH INVESTMENT MANAGEMENT LLC124,381$725
Man Group plc124,211$724
TUDOR INVESTMENT CORP ET AL123,410$719
XTX Topco Ltd119,643$698
MetLife Investment Management, LLC119,103$694
Caption Management, LLC115,000$670
ACADIAN ASSET MANAGEMENT LLC113,270$1
MANUFACTURERS LIFE INSURANCE COMPANY, THE110,220$643
Virtus Investment Advisers, LLC110,048$642
WELLINGTON MANAGEMENT GROUP LLP100,087$584
DekaBank Deutsche Girozentrale100,000$1
HSBC HOLDINGS PLC98,815$582
SEI INVESTMENTS CO98,424$574
Zurcher Kantonalbank (Zurich Cantonalbank)95,934$559
CWM, LLC92,449$1
127 other institutions2,784,357$15,357
Total (227 institutions)166,740,287$964,396