ARIAD PHARMACEUTICALS INC

CUSIP: 04033A100 Class: COM

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 1,000,000 Value ($000) $12,440 Avg Close — Range —
Q3 2016
Shares 1,045,000 Value ($000) $14,306 Avg Close — Range —
Q2 2016
Shares 1,250,000 Value ($000) $9,238 Avg Close — Range —
Q1 2016
Shares 1,250,000 Value ($000) $7,988 Avg Close — Range —
Q4 2015
Shares 1,310,000 Value ($000) $8,188 Avg Close — Range —
Q3 2015
Shares 1,310,000 Value ($000) $7,650 Avg Close — Range —
Q2 2015
Shares 1,500,000 Value ($000) $12,405 Avg Close — Range —
Q1 2015
Shares 1,500,000 Value ($000) $12,360 Avg Close — Range —
Q4 2014
Shares 1,525,000 Value ($000) $10,477 Avg Close — Range —
Q3 2014
Shares 1,500,000 Value ($000) $8,100,000 Avg Close — Range —
Q2 2014
Shares 1,660,000 Value ($000) $10,574 Avg Close — Range —
Q1 2014
Shares 1,670,000 Value ($000) $13,460 Avg Close — Range —
Q4 2013
Shares 1,670,000 Value ($000) $11,857,000 Avg Close — Range —