ARQULE INC

CUSIP: 04269E107 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q4 2019
Shares 297,227 Value ($000) $5,933 Avg Close — Range —
Q3 2019
Shares 2,082,643 Value ($000) $14,933 Avg Close — Range —
Q2 2019
Shares 1,782,643 Value ($000) $19,627 Avg Close — Range —
Q1 2019
Shares 1,432,643 Value ($000) $6,862 Avg Close — Range —
Q4 2018
Shares 2,032,643 Value ($000) $5,630 Avg Close — Range —
Q3 2018
Shares 2,005,243 Value ($000) $11,350 Avg Close — Range —
Q2 2018
Shares 1,497,683 Value ($000) $8,282 Avg Close — Range —
Q1 2018
Shares 2,264,136 Value ($000) $6,521 Avg Close — Range —
Q4 2013
Shares 291,100 Value ($000) $626 Avg Close — Range —