ARROWHEAD PHARMACEUTICALS IN

Ticker: ARWR CUSIP: 04280A100 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 146,064 Value ($000) $9,697 Avg Close $49.01 Range $34.38 - $72.36

Q3 2025

Shares 20,301 Value ($000) $700 Avg Close $21.98 Range $14.30 - $34.61

Q4 2023

Shares 45,474 Value ($000) $1,392 Avg Close $26.56 Range $20.67 - $31.68

Q2 2023

Shares 31,390 Value ($000) $1,119 Avg Close $34.48 Range $24.64 - $42.48

Q1 2023

Shares 30,563 Value ($000) $776 Avg Close $31.45 Range $23.09 - $41.03

Q2 2022

Shares 8,189 Value ($000) $288 Avg Close $37.62 Range $26.81 - $51.11

Q4 2021

Shares 33,117 Value ($000) $2,196 Avg Close $68.71 Range $57.94 - $84.83

Q3 2021

Shares 41,906 Value ($000) $2,616 Avg Close $64.75 Range $57.92 - $86.01

Q2 2021

Shares 60,412 Value ($000) $5,003 Avg Close $74.45 Range $60.52 - $93.66

Q1 2021

Shares 44,185 Value ($000) $2,930 Avg Close $77.59 Range $60.64 - $92.60

Q4 2020

Shares 88,599 Value ($000) $6,799 Avg Close $63.95 Range $42.44 - $86.75

Q3 2020

Shares 262,972 Value ($000) $11,324 Avg Close $43.15 Range $32.86 - $53.12

Q2 2020

Shares 433,518 Value ($000) $18,724 Avg Close $35.29 Range $25.79 - $43.84

Q1 2020

Shares 676,121 Value ($000) $19,452 Avg Close $40.33 Range $19.51 - $64.00

Q4 2019

Shares 692,895 Value ($000) $43,950 Avg Close $49.62 Range $27.11 - $73.72

Q3 2019

Shares 736,236 Value ($000) $20,747 Avg Close $29.59 Range $25.68 - $36.80

Q2 2019

Shares 453,605 Value ($000) $12,020 Avg Close $21.95 Range $17.30 - $28.84

Q1 2019

Shares 539,158 Value ($000) $9,893 Avg Close $16.50 Range $11.67 - $20.60

Q4 2018

Shares 41,186 Value ($000) $512 Avg Close $13.67 Range $10.41 - $20.31

Q3 2018

Shares 68,257 Value ($000) $1,309 Avg Close $16.41 Range $12.25 - $22.39

Q2 2018

Shares 113,909 Value ($000) $1,549 Avg Close $9.35 Range $6.26 - $14.24

Q1 2018

Shares 891,784 Value ($000) $6,430 Avg Close $6.16 Range $3.57 - $8.09

Q4 2017

Shares 1,167,879 Value ($000) $4,298 Avg Close $3.71 Range $3.01 - $4.54

Q3 2017

Shares 971,768 Value ($000) $4,208 Avg Close $2.38 Range $1.48 - $4.42

Q2 2017

Shares 258,301 Value ($000) $418 Avg Close $1.62 Range $1.42 - $2.04

Q1 2017

Shares 85,953 Value ($000) $159 Avg Close $1.98 Range $1.42 - $2.45

Q4 2016

Shares 65,342 Value ($000) $101 Avg Close $4.26 Range $1.20 - $7.74

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	146,064	$9,697	$49.01	$34.38 - $72.36
Q3 2025	20,301	$700	$21.98	$14.30 - $34.61
Q4 2023	45,474	$1,392	$26.56	$20.67 - $31.68
Q2 2023	31,390	$1,119	$34.48	$24.64 - $42.48
Q1 2023	30,563	$776	$31.45	$23.09 - $41.03
Q2 2022	8,189	$288	$37.62	$26.81 - $51.11
Q4 2021	33,117	$2,196	$68.71	$57.94 - $84.83
Q3 2021	41,906	$2,616	$64.75	$57.92 - $86.01
Q2 2021	60,412	$5,003	$74.45	$60.52 - $93.66
Q1 2021	44,185	$2,930	$77.59	$60.64 - $92.60
Q4 2020	88,599	$6,799	$63.95	$42.44 - $86.75
Q3 2020	262,972	$11,324	$43.15	$32.86 - $53.12
Q2 2020	433,518	$18,724	$35.29	$25.79 - $43.84
Q1 2020	676,121	$19,452	$40.33	$19.51 - $64.00
Q4 2019	692,895	$43,950	$49.62	$27.11 - $73.72
Q3 2019	736,236	$20,747	$29.59	$25.68 - $36.80
Q2 2019	453,605	$12,020	$21.95	$17.30 - $28.84
Q1 2019	539,158	$9,893	$16.50	$11.67 - $20.60
Q4 2018	41,186	$512	$13.67	$10.41 - $20.31
Q3 2018	68,257	$1,309	$16.41	$12.25 - $22.39
Q2 2018	113,909	$1,549	$9.35	$6.26 - $14.24
Q1 2018	891,784	$6,430	$6.16	$3.57 - $8.09
Q4 2017	1,167,879	$4,298	$3.71	$3.01 - $4.54
Q3 2017	971,768	$4,208	$2.38	$1.48 - $4.42
Q2 2017	258,301	$418	$1.62	$1.42 - $2.04
Q1 2017	85,953	$159	$1.98	$1.42 - $2.45
Q4 2016	65,342	$101	$4.26	$1.20 - $7.74