| BlackRock, Inc. | 21,318,582 | $1,415,341 |
| VANGUARD GROUP INC | 15,293,121 | $1,015,310 |
| Avoro Capital Advisors LLC | 10,625,000 | $705,394 |
| FMR LLC | 6,520,408 | $432,890 |
| STATE STREET CORP | 6,403,830 | $425,150 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,264,963 | $216,799 |
| Slate Path Capital LP | 2,523,500 | $167,535 |
| BAKER BROS. ADVISORS LP | 2,175,645 | $144,441 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 2,087,953 | $138,619 |
| FRED ALGER MANAGEMENT, LLC | 1,832,997 | $121,693 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,832,946 | $121,689 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,769,340 | $117,466 |
| NORGES BANK | 1,704,464 | $113,159 |
| GOLDMAN SACHS GROUP INC | 1,677,522 | $111,371 |
| Siren, L.L.C. | 1,500,476 | $99,617 |
| MORGAN STANLEY | 1,476,005 | $97,992 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,353,719 | $89,873 |
| NORTHERN TRUST CORP | 1,346,257 | $89,378 |
| Fisher Asset Management, LLC | 1,311,727 | $87,086 |
| JANUS HENDERSON GROUP PLC | 1,280,446 | $84,997 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,260,380 | $83,677 |
| Pictet Asset Management Holding SA | 1,028,736 | $68,636 |
| UBS Group AG | 987,287 | $65,546 |
| Vestal Point Capital, LP | 900,000 | $59,751 |
| Bank of New York Mellon Corp | 887,848 | $58,944 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 838,818 | $56 |
| Western Financial Corp/CA | 820,239 | $54,456 |
| PRINCIPAL FINANCIAL GROUP INC | 715,539 | $47,505 |
| Assenagon Asset Management S.A. | 684,889 | $45,470 |
| Connor, Clark & Lunn Investment Management Ltd. | 663,262 | $44,034 |
| BANK OF AMERICA CORP /DE/ | 622,029 | $41,297 |
| JPMORGAN CHASE & CO | 611,910 | $40,625 |
| RTW INVESTMENTS, LP | 584,716 | $38,819 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | $36,515 |
| Invesco Ltd. | 547,758 | $36,366 |
| Public Sector Pension Investment Board | 478,514 | $31,769 |
| CITADEL ADVISORS LLC | 474,259 | $31,486 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 470,000 | $31,203 |
| Voya Investment Management LLC | 422,731 | $28,065 |
| Woodline Partners LP | 400,184 | $26,568 |
| Privium Fund Management B.V. | 398,204 | $26,437 |
| Legal & General Group Plc | 395,311 | $26,245 |
| BALYASNY ASSET MANAGEMENT L.P. | 376,216 | $24,977 |
| Alyeska Investment Group, L.P. | 375,371 | $24,921 |
| EVENTIDE ASSET MANAGEMENT, LLC | 370,000 | $24,564 |
| RHUMBLINE ADVISERS | 352,395 | $23,395 |
| NORDEA INVESTMENT MANAGEMENT AB | 324,251 | $21,566 |
| BARCLAYS PLC | 321,833 | $21,366 |
| Nuveen, LLC | 288,578 | $19,159 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 288,511 | $19,154 |
| abrdn plc | 286,146 | $18,997 |
| FengHe Fund Management Pte. Ltd. | 266,700 | $17,706 |
| AMERIPRISE FINANCIAL INC | 257,477 | $17,094 |
| Trexquant Investment LP | 250,944 | $16,660 |
| Swiss National Bank | 245,400 | $16,292 |
| DEUTSCHE BANK AG\ | 242,074 | $16,071 |
| FIRST TRUST ADVISORS LP | 237,730 | $15,783 |
| Clearbridge Investments, LLC | 208,062 | $13,813 |
| RAYMOND JAMES FINANCIAL INC | 198,387 | $13,171 |
| Hillsdale Investment Management Inc. | 193,850 | $12,870 |
| PINNACLE ASSOCIATES LTD | 191,669 | $12,725 |
| ALLIANCEBERNSTEIN L.P. | 172,666 | $11,463 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 159,538 | $10,592 |
| Skandinaviska Enskilda Banken AB (publ) | 159,532 | $10,590 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 158,622 | $10,531 |
| WELLS FARGO & COMPANY/MN | 152,507 | $10,125 |
| PRUDENTIAL FINANCIAL INC | 152,225 | $10,106 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 149,776 | $10 |
| DIMENSIONAL FUND ADVISORS LP | 147,412 | $9,787 |
| AQR CAPITAL MANAGEMENT LLC | 147,353 | $9,783 |
| D. E. Shaw & Co., Inc. | 146,064 | $9,697 |
| Rhenman & Partners Asset Management AB | 144,500 | $9,593 |
| WEALTH EFFECTS LLC | 143,300 | $9,514 |
| WCM INVESTMENT MANAGEMENT, LLC | 138,905 | $9,341 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 133,875 | $8,892 |
| HighTower Advisors, LLC | 133,229 | $8,845 |
| MARSHALL WACE, LLP | 123,855 | $8,223 |
| Russell Investments Group, Ltd. | 122,115 | $8,107 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 118,750 | $8 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 118,372 | $7,859 |
| SEI INVESTMENTS CO | 112,279 | $7,454 |
| Weiss Asset Management LP | 111,375 | $7,394 |
| FRANKLIN RESOURCES INC | 107,366 | $7,128 |
| NEUBERGER BERMAN GROUP LLC | 100,385 | $6,665 |
| LPL Financial LLC | 100,277 | $6,657 |
| Integral Health Asset Management, LLC | 100,000 | $6,639 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 98,151 | $6,547 |
| Tetragon Partners GP Ltd | 96,935 | $6,436 |
| Thrivent Financial for Lutherans | 95,001 | $6 |
| VICTORY CAPITAL MANAGEMENT INC | 92,623 | $6,149 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 89,484 | $5,941 |
| Rafferty Asset Management, LLC | 84,469 | $5,608 |
| Aquatic Capital Management LLC | 80,958 | $5,375 |
| STATE OF WISCONSIN INVESTMENT BOARD | 79,214 | $5,259 |
| ACT CAPITAL MANAGEMENT, LLC | 75,000 | $4,979 |
| Pinion Investment Advisors, LLC | 75,000 | $4,979 |
| Creative Planning | 74,421 | $4,941 |
| MetLife Investment Management, LLC | 73,040 | $4,849 |
| Erste Asset Management GmbH | 73,000 | $5,082 |
| State of Alaska, Department of Revenue | 70,399 | $5 |
| 298 other institutions | 4,159,449 | $247,087 |