ARROWHEAD PHARMACEUTICALS IN

Ticker: ARWR CUSIP: 04280A100 Class: Common Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 5,701 Value ($000) $378 Avg Close $49.01 Range $34.38 - $72.36

Q3 2021

Shares 4,366 Value ($000) $273 Avg Close $64.75 Range $57.92 - $86.01

Q4 2019

Shares 4,438 Value ($000) $282 Avg Close $49.62 Range $27.11 - $73.72

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	5,701	$378	$49.01	$34.38 - $72.36
Q3 2021	4,366	$273	$64.75	$57.92 - $86.01
Q4 2019	4,438	$282	$49.62	$27.11 - $73.72