ARROWHEAD PHARMACEUTICALS IN

Ticker: ARWR CUSIP: 04280A100 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 6,200 Value ($000) $412 Avg Close $49.01 Range $34.38 - $72.36

Q3 2025

Shares 21,734 Value ($000) $750 Avg Close $21.98 Range $14.30 - $34.61

Q2 2025

Shares 391,800 Value ($000) $6,190 Avg Close $14.35 Range $9.57 - $17.49

Q1 2025

Shares 723,800 Value ($000) $9,221 Avg Close $18.18 Range $12.14 - $21.84

Q4 2024

Shares 430,700 Value ($000) $8,097 Avg Close $20.59 Range $17.05 - $27.34

Q3 2024

Shares 100,000 Value ($000) $1,937 Avg Close $24.41 Range $19.07 - $30.41

Q2 2024

Shares 102,100 Value ($000) $2,654 Avg Close $24.57 Range $21.39 - $28.50

Q1 2024

Shares 38,800 Value ($000) $1,110 Avg Close $31.99 Range $27.00 - $39.83

Q4 2023

Shares 77,500 Value ($000) $2,372 Avg Close $26.56 Range $20.67 - $31.68

Q3 2023

Shares 142,900 Value ($000) $3,840 Avg Close $30.63 Range $26.04 - $36.43

Q2 2023

Shares 51,900 Value ($000) $1,851 Avg Close $34.48 Range $24.64 - $42.48

Q1 2023

Shares 32,000 Value ($000) $813 Avg Close $31.45 Range $23.09 - $41.03

Q3 2021

Shares 20,300 Value ($000) $1,267 Avg Close $64.75 Range $57.92 - $86.01

Q2 2021

Shares 53,800 Value ($000) $4,456 Avg Close $74.45 Range $60.52 - $93.66

Q1 2021

Shares 99,800 Value ($000) $6,618 Avg Close $77.59 Range $60.64 - $92.60

Q4 2020

Shares 54,200 Value ($000) $4,159 Avg Close $63.95 Range $42.44 - $86.75

Q3 2020

Shares 195,300 Value ($000) $8,410 Avg Close $43.15 Range $32.86 - $53.12

Q2 2020

Shares 663,100 Value ($000) $28,639 Avg Close $35.29 Range $25.79 - $43.84

Q1 2020

Shares 625,500 Value ($000) $17,996 Avg Close $40.33 Range $19.51 - $64.00

Q4 2019

Shares 154,200 Value ($000) $9,781 Avg Close $49.62 Range $27.11 - $73.72

Q3 2019

Shares 104,000 Value ($000) $2,931 Avg Close $29.59 Range $25.68 - $36.80

Q2 2019

Shares 242,400 Value ($000) $6,424 Avg Close $21.95 Range $17.30 - $28.84

Q1 2019

Shares 74,700 Value ($000) $1,371 Avg Close $16.50 Range $11.67 - $20.60

Q3 2018

Shares 20,000 Value ($000) $383 Avg Close $16.41 Range $12.25 - $22.39

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	6,200	$412	$49.01	$34.38 - $72.36
Q3 2025	21,734	$750	$21.98	$14.30 - $34.61
Q2 2025	391,800	$6,190	$14.35	$9.57 - $17.49
Q1 2025	723,800	$9,221	$18.18	$12.14 - $21.84
Q4 2024	430,700	$8,097	$20.59	$17.05 - $27.34
Q3 2024	100,000	$1,937	$24.41	$19.07 - $30.41
Q2 2024	102,100	$2,654	$24.57	$21.39 - $28.50
Q1 2024	38,800	$1,110	$31.99	$27.00 - $39.83
Q4 2023	77,500	$2,372	$26.56	$20.67 - $31.68
Q3 2023	142,900	$3,840	$30.63	$26.04 - $36.43
Q2 2023	51,900	$1,851	$34.48	$24.64 - $42.48
Q1 2023	32,000	$813	$31.45	$23.09 - $41.03
Q3 2021	20,300	$1,267	$64.75	$57.92 - $86.01
Q2 2021	53,800	$4,456	$74.45	$60.52 - $93.66
Q1 2021	99,800	$6,618	$77.59	$60.64 - $92.60
Q4 2020	54,200	$4,159	$63.95	$42.44 - $86.75
Q3 2020	195,300	$8,410	$43.15	$32.86 - $53.12
Q2 2020	663,100	$28,639	$35.29	$25.79 - $43.84
Q1 2020	625,500	$17,996	$40.33	$19.51 - $64.00
Q4 2019	154,200	$9,781	$49.62	$27.11 - $73.72
Q3 2019	104,000	$2,931	$29.59	$25.68 - $36.80
Q2 2019	242,400	$6,424	$21.95	$17.30 - $28.84
Q1 2019	74,700	$1,371	$16.50	$11.67 - $20.60
Q3 2018	20,000	$383	$16.41	$12.25 - $22.39