ARROWHEAD PHARMACEUTICALS IN

Ticker: ARWR CUSIP: 04280A100 Class: Common Stock

JANE STREET GROUP, LLC's Holding History (CIK: 0001595888)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 5,671 Value ($000) $376 Avg Close $49.01 Range $34.38 - $72.36

Q2 2025

Shares 22,243 Value ($000) $351 Avg Close $14.35 Range $9.57 - $17.49

Q1 2025

Shares 39,882 Value ($000) $508 Avg Close $18.18 Range $12.14 - $21.84

Q4 2024

Shares 656,256 Value ($000) $12,338 Avg Close $20.59 Range $17.05 - $27.34

Q3 2024

Shares 463,880 Value ($000) $8,985 Avg Close $24.41 Range $19.07 - $30.41

Q2 2024

Shares 696,719 Value ($000) $18,108 Avg Close $24.57 Range $21.39 - $28.50

Q1 2024

Shares 128,072 Value ($000) $3,663 Avg Close $31.99 Range $27.00 - $39.83

Q4 2023

Shares 83,031 Value ($000) $2,541 Avg Close $26.56 Range $20.67 - $31.68

Q3 2023

Shares 124,003 Value ($000) $3,332 Avg Close $30.63 Range $26.04 - $36.43

Q2 2023

Shares 97,530 Value ($000) $3,478 Avg Close $34.48 Range $24.64 - $42.48

Q1 2023

Shares 75,497 Value ($000) $1,918 Avg Close $31.45 Range $23.09 - $41.03

Q4 2022

Shares 24,600 Value ($000) $1,125 Avg Close $33.13 Range $27.75 - $40.62

Q3 2022

Shares 36,208 Value ($000) $1,300 Avg Close $40.36 Range $29.60 - $48.48

Q2 2022

Shares 78,778 Value ($000) $2,884 Avg Close $37.62 Range $26.81 - $51.11

Q1 2022

Shares 73,051 Value ($000) $3,359 Avg Close $49.51 Range $38.89 - $70.09

Q4 2021

Shares 21,563 Value ($000) $1,430 Avg Close $68.71 Range $57.94 - $84.83

Q3 2021

Shares 58,012 Value ($000) $3,622 Avg Close $64.75 Range $57.92 - $86.01

Q2 2021

Shares 81,704 Value ($000) $6,766 Avg Close $74.45 Range $60.52 - $93.66

Q1 2021

Shares 15,487 Value ($000) $1,027 Avg Close $77.59 Range $60.64 - $92.60

Q4 2020

Shares 42,821 Value ($000) $3,286 Avg Close $63.95 Range $42.44 - $86.75

Q3 2020

Shares 101,198 Value ($000) $4,358 Avg Close $43.15 Range $32.86 - $53.12

Q2 2020

Shares 20,107 Value ($000) $868 Avg Close $35.29 Range $25.79 - $43.84

Q1 2020

Shares 7,281 Value ($000) $209 Avg Close $40.33 Range $19.51 - $64.00

Q4 2019

Shares 29,261 Value ($000) $1,856 Avg Close $49.62 Range $27.11 - $73.72

Q3 2019

Shares 22,280 Value ($000) $628 Avg Close $29.59 Range $25.68 - $36.80

Q1 2019

Shares 46,052 Value ($000) $845 Avg Close $16.50 Range $11.67 - $20.60

Q4 2018

Shares 16,385 Value ($000) $204 Avg Close $13.67 Range $10.41 - $20.31

Q2 2018

Shares 33,279 Value ($000) $453 Avg Close $9.35 Range $6.26 - $14.24

Q4 2017

Shares 35,299 Value ($000) $130 Avg Close $3.71 Range $3.01 - $4.54

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	5,671	$376	$49.01	$34.38 - $72.36
Q2 2025	22,243	$351	$14.35	$9.57 - $17.49
Q1 2025	39,882	$508	$18.18	$12.14 - $21.84
Q4 2024	656,256	$12,338	$20.59	$17.05 - $27.34
Q3 2024	463,880	$8,985	$24.41	$19.07 - $30.41
Q2 2024	696,719	$18,108	$24.57	$21.39 - $28.50
Q1 2024	128,072	$3,663	$31.99	$27.00 - $39.83
Q4 2023	83,031	$2,541	$26.56	$20.67 - $31.68
Q3 2023	124,003	$3,332	$30.63	$26.04 - $36.43
Q2 2023	97,530	$3,478	$34.48	$24.64 - $42.48
Q1 2023	75,497	$1,918	$31.45	$23.09 - $41.03
Q4 2022	24,600	$1,125	$33.13	$27.75 - $40.62
Q3 2022	36,208	$1,300	$40.36	$29.60 - $48.48
Q2 2022	78,778	$2,884	$37.62	$26.81 - $51.11
Q1 2022	73,051	$3,359	$49.51	$38.89 - $70.09
Q4 2021	21,563	$1,430	$68.71	$57.94 - $84.83
Q3 2021	58,012	$3,622	$64.75	$57.92 - $86.01
Q2 2021	81,704	$6,766	$74.45	$60.52 - $93.66
Q1 2021	15,487	$1,027	$77.59	$60.64 - $92.60
Q4 2020	42,821	$3,286	$63.95	$42.44 - $86.75
Q3 2020	101,198	$4,358	$43.15	$32.86 - $53.12
Q2 2020	20,107	$868	$35.29	$25.79 - $43.84
Q1 2020	7,281	$209	$40.33	$19.51 - $64.00
Q4 2019	29,261	$1,856	$49.62	$27.11 - $73.72
Q3 2019	22,280	$628	$29.59	$25.68 - $36.80
Q1 2019	46,052	$845	$16.50	$11.67 - $20.60
Q4 2018	16,385	$204	$13.67	$10.41 - $20.31
Q2 2018	33,279	$453	$9.35	$6.26 - $14.24
Q4 2017	35,299	$130	$3.71	$3.01 - $4.54