| RA CAPITAL MANAGEMENT, L.P. | 10,281,496 | $2,192,426 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,185,696 | $1,105,798 |
| Avoro Capital Advisors LLC | 5,111,111 | $1,089,893 |
| FMR LLC | 4,153,311 | $885,652 |
| JANUS HENDERSON GROUP PLC | 4,061,641 | $866,104 |
| Artisan Partners Limited Partnership | 3,225,885 | $687,888 |
| Capital International Investors | 3,063,943 | $653,355 |
| FRANKLIN RESOURCES INC | 1,910,079 | $407,305 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,886,393 | $402,254 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,762,721 | $375,883 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,570,260 | $335 |
| AMERICAN CENTURY COMPANIES INC | 1,443,141 | $307,737 |
| PERCEPTIVE ADVISORS LLC | 1,081,421 | $230,602 |
| T. Rowe Price Investment Management, Inc. | 1,080,224 | $230 |
| PRINCIPAL FINANCIAL GROUP INC | 1,026,407 | $218,871 |
| BlackRock, Inc. | 628,200 | $133,957 |
| MORGAN STANLEY | 617,968 | $131,776 |
| GOLDMAN SACHS GROUP INC | 596,703 | $127,241 |
| Invesco Ltd. | 586,094 | $124,979 |
| AMERIPRISE FINANCIAL INC | 550,477 | $117,384 |
| CITADEL ADVISORS LLC | 519,516 | $110,782 |
| JPMORGAN CHASE & CO | 507,240 | $108,164 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 496,837 | $105,946 |
| FIL Ltd | 478,641 | $102,065 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 470,951 | $100,426 |
| Spyglass Capital Management LLC | 415,549 | $88,612 |
| Polar Capital Holdings Plc | 370,473 | $79,000 |
| FRED ALGER MANAGEMENT, LLC | 352,109 | $75,084 |
| UBS Group AG | 308,190 | $65,718 |
| BNP PARIBAS ARBITRAGE, SA | 307,086 | $65,483 |
| DEUTSCHE BANK AG\ | 296,818 | $63,293 |
| ALLIANCEBERNSTEIN L.P. | 288,592 | $61,539 |
| SEI INVESTMENTS CO | 281,473 | $60,021 |
| Tri Locum Partners LP | 265,015 | $56,512 |
| MILLENNIUM MANAGEMENT LLC | 262,329 | $55,939 |
| TWO SIGMA INVESTMENTS, LP | 247,892 | $52,860 |
| Siren, L.L.C. | 235,862 | $50,295 |
| TD Asset Management Inc | 234,012 | $49,901 |
| abrdn plc | 221,677 | $47,270 |
| Jain Global LLC | 216,526 | $46,172 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 216,173 | $46,097 |
| Rock Springs Capital Management LP | 203,500 | $43,394 |
| Bank of New York Mellon Corp | 194,605 | $41,497 |
| Qube Research & Technologies Ltd | 193,464 | $41,254 |
| Q Global Advisors, LLC | 190,000 | $41 |
| Allspring Global Investments Holdings, LLC | 187,642 | $40,022 |
| Candriam S.C.A. | 186,940 | $39,865 |
| NEW YORK STATE COMMON RETIREMENT FUND | 182,234 | $38,860 |
| PFM Health Sciences, LP | 177,685 | $37,890 |
| Vestal Point Capital, LP | 175,000 | $37,317 |
| ARS Investment Partners, LLC | 174,611 | $37,234 |
| ORBIMED ADVISORS LLC | 171,977 | $36,672 |
| BANK OF AMERICA CORP /DE/ | 162,503 | $34,652 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 156,272 | $33,323 |
| RICE HALL JAMES & ASSOCIATES, LLC | 145,046 | $30,930 |
| Frazier Life Sciences Management, L.P. | 133,333 | $28,432 |
| First Turn Management, LLC | 131,808 | $28,107 |
| ODDO BHF ASSET MANAGEMENT SAS | 129,941 | $27,709 |
| D. E. Shaw & Co., Inc. | 125,768 | $26,819 |
| MOORE CAPITAL MANAGEMENT, LP | 125,000 | $26,655 |
| LORD, ABBETT & CO. LLC | 120,197 | $26 |
| Catalio Capital Management, LP | 119,265 | $25,432 |
| BRAUN STACEY ASSOCIATES INC | 119,095 | $25,396 |
| IMC-Chicago, LLC | 113,682 | $24,242 |
| LOOMIS SAYLES & CO L P | 112,240 | $23,934 |
| 1832 Asset Management L.P. | 110,000 | $23,456 |
| Woodline Partners LP | 102,461 | $21,849 |
| Cormorant Asset Management, LP | 100,000 | $21,324 |
| BAROMETER CAPITAL MANAGEMENT INC. | 91,392 | $10,837 |
| Integral Health Asset Management, LLC | 90,000 | $19,192 |
| Resolute Capital Asset Partners LLC | 88,627 | $18,899 |
| Defilade Capital Management, L.P. | 85,694 | $18,273 |
| ExodusPoint Capital Management, LP | 82,888 | $17,675 |
| Beck Bode, LLC | 81,087 | $17,291 |
| Pictet Asset Management Holding SA | 73,418 | $15,493 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 73,310 | $15,633 |
| BNP Paribas Investment Partners S.A. | 72,106 | $15 |
| CANADA PENSION PLAN INVESTMENT BOARD | 71,516 | $15,250 |
| Ensign Peak Advisors, Inc | 69,560 | $14,833 |
| Voleon Capital Management LP | 69,389 | $14,797 |
| GEODE CAPITAL MANAGEMENT, LLC | 68,855 | $14,683 |
| STATE STREET CORP | 67,949 | $14,489 |
| CASTLEARK MANAGEMENT LLC | 66,336 | $14,145 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60,895 | $12,748 |
| Trexquant Investment LP | 59,025 | $12,586 |
| Voya Investment Management LLC | 57,075 | $12,171 |
| Chevy Chase Trust Holdings, LLC | 56,695 | $12,090 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 49,228 | $10,497 |
| Brevan Howard Capital Management LP | 48,260 | $10,152 |
| Eversept Partners, LP | 48,241 | $10,287 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 48,097 | $10,256 |
| TWO SIGMA ADVISERS, LP | 47,400 | $10,108 |
| NOMURA ASSET MANAGEMENT CO LTD | 43,701 | $9,319 |
| VICTORY CAPITAL MANAGEMENT INC | 43,190 | $9,210 |
| Diversified Trust Co | 42,251 | $9,010 |
| LAZARD ASSET MANAGEMENT LLC | 39,135 | $8,345 |
| Skandinaviska Enskilda Banken AB (publ) | 38,990 | $8,314 |
| Empowered Funds, LLC | 36,697 | $7,825 |
| Russell Investments Group, Ltd. | 34,910 | $7,444 |
| WELLS FARGO & COMPANY/MN | 33,780 | $7,203 |
| 201 other institutions | 1,287,469 | $248,223 |