| BVF INC/IL | 1,355,257 | $24,611 |
| Nantahala Capital Management, LLC | 1,235,000 | $22,428 |
| ORBIMED ADVISORS LLC | 1,187,300 | $21,561 |
| Affinity Asset Advisors, LLC | 1,051,054 | $19,087 |
| Caligan Partners LP | 881,533 | $16,009 |
| VANGUARD GROUP INC | 804,084 | $14,602 |
| RA CAPITAL MANAGEMENT, L.P. | 662,968 | $12,039 |
| MILLENNIUM MANAGEMENT LLC | 659,979 | $11,985 |
| Point72 Asset Management, L.P. | 627,502 | $11,395 |
| BANK OF AMERICA CORP /DE/ | 621,350 | $11,284 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 550,000 | $9,988 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 524,436 | $9,524 |
| MARSHALL WACE, LLP | 507,550 | $9,217 |
| Commodore Capital LP | 483,000 | $8,771 |
| TCG Crossover Management, LLC | 483,000 | $8,771 |
| UBS Group AG | 477,816 | $8,677 |
| JENNISON ASSOCIATES LLC | 475,625 | $8,637 |
| Soleus Capital Management, L.P. | 441,978 | $8,026 |
| BALYASNY ASSET MANAGEMENT L.P. | 439,312 | $7,978 |
| CITADEL ADVISORS LLC | 419,491 | $7,618 |
| Patient Square Capital LP | 311,966 | $5,665 |
| BlackRock, Inc. | 289,571 | $5,259 |
| Boxer Capital Management, LLC | 275,000 | $4,994 |
| MORGAN STANLEY | 264,907 | $4,811 |
| Velan Capital Investment Management LP | 263,642 | $4,788 |
| FMR LLC | 220,300 | $4,001 |
| AMERIPRISE FINANCIAL INC | 217,974 | $3,958 |
| Jain Global LLC | 217,292 | $3,946 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 210,994 | $3,832 |
| BOOTHBAY FUND MANAGEMENT, LLC | 202,127 | $3,671 |
| BNP PARIBAS ARBITRAGE, SA | 197,747 | $3,591 |
| SummitTX Capital, L.P. | 195,873 | $3,557 |
| NAN FUNG TRINITY (HK) LTD | 189,000 | $3,432 |
| JANE STREET GROUP, LLC | 178,855 | $3,248 |
| GEODE CAPITAL MANAGEMENT, LLC | 166,152 | $3,018 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 153,313 | $2,784 |
| DEUTSCHE BANK AG\ | 150,000 | $2,724 |
| TWO SIGMA INVESTMENTS, LP | 148,237 | $2,692 |
| PERCEPTIVE ADVISORS LLC | 139,667 | $2,536 |
| STEMPOINT CAPITAL LP | 135,552 | $2,462 |
| Moody Aldrich Partners LLC | 133,231 | $2,419 |
| Squadron Capital Management LLC | 130,000 | $2,361 |
| GREAT POINT PARTNERS LLC | 124,666 | $2,264 |
| BARCLAYS PLC | 105,814 | $1,922 |
| HighVista Strategies LLC | 95,631 | $1,737 |
| abrdn plc | 95,426 | $1,733 |
| FRED ALGER MANAGEMENT, LLC | 80,092 | $1,454 |
| STATE STREET CORP | 79,254 | $1,439 |
| Sio Capital Management, LLC | 72,173 | $1,311 |
| GOLDMAN SACHS GROUP INC | 65,313 | $1,186 |
| Qube Research & Technologies Ltd | 64,463 | $1,171 |
| Seven Fleet Capital Management LP | 63,343 | $1,150 |
| 683 Capital Management, LLC | 56,850 | $1,032 |
| Quadrature Capital Ltd | 53,044 | $963 |
| Caption Management, LLC | 52,641 | $956 |
| Woodline Partners LP | 52,041 | $945 |
| Atom Investors LP | 51,194 | $930 |
| TWO SIGMA ADVISERS, LP | 49,400 | $897 |
| JPMORGAN CHASE & CO | 44,431 | $807 |
| Walleye Capital LLC | 41,693 | $757 |
| Artia Global Partners LP | 41,570 | $755 |
| Squarepoint Ops LLC | 40,854 | $742 |
| XTX Topco Ltd | 40,458 | $735 |
| ExodusPoint Capital Management, LP | 32,267 | $586 |
| NORTHERN TRUST CORP | 32,204 | $585 |
| Ikarian Capital, LLC | 31,106 | $565 |
| GLENMEDE TRUST CO NA | 20,450 | $371 |
| OMERS ADMINISTRATION Corp | 19,600 | $356 |
| RENAISSANCE TECHNOLOGIES LLC | 18,300 | $332 |
| Hudson Bay Capital Management LP | 16,771 | $305 |
| ENVESTNET ASSET MANAGEMENT INC | 16,039 | $291 |
| Persistent Asset Partners Ltd | 15,087 | $274 |
| Jump Financial, LLC | 13,092 | $238 |
| Tower Research Capital LLC (TRC) | 8,737 | $159 |
| Belvedere Trading LLC | 4,526 | $82 |
| US BANCORP \DE\ | 2,733 | $50 |
| PFS Partners, LLC | 2,000 | $36 |
| ACADIAN ASSET MANAGEMENT LLC | 1,471 | $0 |
| CITIGROUP INC | 1,143 | $21 |
| GROUP ONE TRADING, L.P. | 1 | $0 |
| OSAIC HOLDINGS, INC. | 1 | $0 |
| Parallel Advisors, LLC | 1 | $0 |
| Key Financial Inc | 1 | $0 |
| Activest Wealth Management | 1 | $0 |