AXSOME THERAPEUTICS INC

Ticker: AXSM CUSIP: 05464T104 Class: Common Stock

STATE OF WISCONSIN INVESTMENT BOARD's Holding History (CIK: 0000854157)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 26,603 Value ($000) $4,859 Avg Close $139.61 Range $117.30 - $184.40

Q3 2025

Shares 30,325 Value ($000) $3,683 Avg Close $112.64 Range $96.09 - $130.00

Q2 2025

Shares 25,847 Value ($000) $2,698 Avg Close $105.89 Range $86.99 - $120.00

Q1 2025

Shares 30,780 Value ($000) $3,590 Avg Close $113.93 Range $79.19 - $139.13

Q4 2024

Shares 27,379 Value ($000) $2,317 Avg Close $91.96 Range $75.56 - $105.00

Q3 2024

Shares 25,358 Value ($000) $2,279 Avg Close $87.29 Range $72.21 - $97.00

Q2 2024

Shares 23,358 Value ($000) $1,880 Avg Close $74.04 Range $64.11 - $80.98

Q1 2024

Shares 22,341 Value ($000) $1,783 Avg Close $83.94 Range $68.59 - $98.40

Q4 2023

Shares 25,218 Value ($000) $2,007 Avg Close $66.86 Range $55.02 - $84.24

Q3 2023

Shares 29,157 Value ($000) $2,038 Avg Close $74.75 Range $67.52 - $83.30

Q2 2023

Shares 38,245 Value ($000) $2,748 Avg Close $73.77 Range $56.75 - $91.29

Q1 2023

Shares 29,596 Value ($000) $1,825 Avg Close $65.70 Range $53.71 - $77.70

Q4 2022

Shares 30,268 Value ($000) $2,335 Avg Close $59.77 Range $38.87 - $82.00

Q3 2022

Shares 29,039 Value ($000) $1,296 Avg Close $49.97 Range $35.16 - $71.98

Q2 2022

Shares 27,218 Value ($000) $1,042 Avg Close $31.63 Range $20.63 - $47.40

Q1 2022

Shares 39,500 Value ($000) $1,635 Avg Close $31.00 Range $21.85 - $41.95

Q4 2021

Shares 39,500 Value ($000) $1,492 Avg Close $36.79 Range $29.60 - $44.83

Q3 2021

Shares 39,500 Value ($000) $1,302 Avg Close $38.97 Range $19.38 - $68.74

Q2 2021

Shares 39,500 Value ($000) $2,665 Avg Close $60.01 Range $50.05 - $74.10

Q1 2021

Shares 39,500 Value ($000) $2,236 Avg Close $70.34 Range $55.30 - $82.98

Q4 2020

Shares 42,000 Value ($000) $3,422 Avg Close $74.78 Range $65.00 - $87.24

Q3 2020

Shares 49,000 Value ($000) $3,491 Avg Close $77.92 Range $65.25 - $90.00

Q2 2020

Shares 45,500 Value ($000) $3,744 Avg Close $76.97 Range $49.12 - $109.53

Q1 2020

Shares 41,700 Value ($000) $2,453 Avg Close $81.48 Range $35.44 - $104.79

Q4 2019

Shares 36,500 Value ($000) $3,773 Avg Close $40.39 Range $13.64 - $109.94

Q3 2019

Shares 36,500 Value ($000) $739 Avg Close $25.70 Range $20.10 - $30.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	26,603	$4,859	$139.61	$117.30 - $184.40
Q3 2025	30,325	$3,683	$112.64	$96.09 - $130.00
Q2 2025	25,847	$2,698	$105.89	$86.99 - $120.00
Q1 2025	30,780	$3,590	$113.93	$79.19 - $139.13
Q4 2024	27,379	$2,317	$91.96	$75.56 - $105.00
Q3 2024	25,358	$2,279	$87.29	$72.21 - $97.00
Q2 2024	23,358	$1,880	$74.04	$64.11 - $80.98
Q1 2024	22,341	$1,783	$83.94	$68.59 - $98.40
Q4 2023	25,218	$2,007	$66.86	$55.02 - $84.24
Q3 2023	29,157	$2,038	$74.75	$67.52 - $83.30
Q2 2023	38,245	$2,748	$73.77	$56.75 - $91.29
Q1 2023	29,596	$1,825	$65.70	$53.71 - $77.70
Q4 2022	30,268	$2,335	$59.77	$38.87 - $82.00
Q3 2022	29,039	$1,296	$49.97	$35.16 - $71.98
Q2 2022	27,218	$1,042	$31.63	$20.63 - $47.40
Q1 2022	39,500	$1,635	$31.00	$21.85 - $41.95
Q4 2021	39,500	$1,492	$36.79	$29.60 - $44.83
Q3 2021	39,500	$1,302	$38.97	$19.38 - $68.74
Q2 2021	39,500	$2,665	$60.01	$50.05 - $74.10
Q1 2021	39,500	$2,236	$70.34	$55.30 - $82.98
Q4 2020	42,000	$3,422	$74.78	$65.00 - $87.24
Q3 2020	49,000	$3,491	$77.92	$65.25 - $90.00
Q2 2020	45,500	$3,744	$76.97	$49.12 - $109.53
Q1 2020	41,700	$2,453	$81.48	$35.44 - $104.79
Q4 2019	36,500	$3,773	$40.39	$13.64 - $109.94
Q3 2019	36,500	$739	$25.70	$20.10 - $30.50