| VANGUARD GROUP INC | 4,164,818 | $760,662 |
| BlackRock, Inc. | 3,913,543 | $714,769 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,509,870 | $276 |
| Invesco Ltd. | 1,273,494 | $232,591 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,221,656 | $223,123 |
| FMR LLC | 1,181,622 | $215,811 |
| Deep Track Capital, LP | 1,150,000 | $210,036 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,010,249 | $184,544 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 989,447 | $180,713 |
| STATE STREET CORP | 958,150 | $174,997 |
| RTW INVESTMENTS, LP | 888,001 | $162,185 |
| ALETHEA CAPITAL MANAGEMENT, LLC | 668,710 | $122,133 |
| BANK OF AMERICA CORP /DE/ | 618,033 | $112,877 |
| EVENTIDE ASSET MANAGEMENT, LLC | 571,226 | $104,195 |
| D. E. Shaw & Co., Inc. | 549,113 | $100,290 |
| NORGES BANK | 495,456 | $90,490 |
| MORGAN STANLEY | 491,201 | $89,713 |
| Assenagon Asset Management S.A. | 467,982 | $85,472 |
| Pictet Asset Management Holding SA | 436,063 | $79,643 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 402,700 | $73,549 |
| NORTHERN TRUST CORP | 390,431 | $71,308 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 367,578 | $67,134 |
| Hood River Capital Management LLC | 366,176 | $66,878 |
| PRINCIPAL FINANCIAL GROUP INC | 363,114 | $66,319 |
| UBS Group AG | 355,318 | $64,895 |
| Nuveen, LLC | 349,209 | $63,780 |
| FRANKLIN RESOURCES INC | 342,573 | $62,568 |
| Qube Research & Technologies Ltd | 325,440 | $59,438 |
| MARSHALL WACE, LLP | 320,568 | $58,549 |
| LOOMIS SAYLES & CO L P | 315,391 | $57,603 |
| BNP PARIBAS ARBITRAGE, SA | 304,388 | $55,593 |
| GOLDMAN SACHS GROUP INC | 300,906 | $54,957 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 278,835 | $50,926 |
| Bank of New York Mellon Corp | 255,097 | $46,591 |
| ORBIMED ADVISORS LLC | 253,121 | $46,230 |
| PFM Health Sciences, LP | 251,562 | $45,945 |
| JPMORGAN CHASE & CO | 233,191 | $42,590 |
| Man Group plc | 228,641 | $41,759 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 220,518 | $40,275 |
| Vestal Point Capital, LP | 210,000 | $38,354 |
| First Turn Management, LLC | 206,921 | $37,792 |
| CITIGROUP INC | 204,104 | $37,278 |
| Tri Locum Partners LP | 201,627 | $36,825 |
| TWO SIGMA ADVISERS, LP | 188,500 | $34,428 |
| Connor, Clark & Lunn Investment Management Ltd. | 188,258 | $34,383 |
| Voya Investment Management LLC | 173,301 | $31,652 |
| RENAISSANCE TECHNOLOGIES LLC | 170,000 | $31,049 |
| MetLife Investment Management, LLC | 164,871 | $30,112 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 157,691 | $28,801 |
| Squarepoint Ops LLC | 155,000 | $28,309 |
| Woodline Partners LP | 150,864 | $27,554 |
| RAYMOND JAMES FINANCIAL INC | 150,098 | $24,783 |
| ALGERT GLOBAL LLC | 149,392 | $27 |
| PERCEPTIVE ADVISORS LLC | 148,900 | $27,195 |
| TWO SIGMA INVESTMENTS, LP | 145,597 | $26,592 |
| CITADEL ADVISORS LLC | 138,213 | $25,243 |
| JANE STREET GROUP, LLC | 137,283 | $25,073 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 133,884 | $23,659 |
| US BANCORP \DE\ | 130,985 | $23,923 |
| Rhenman & Partners Asset Management AB | 114,800 | $20,967 |
| WCM INVESTMENT MANAGEMENT, LLC | 112,058 | $16,673 |
| Voleon Capital Management LP | 110,179 | $20,123 |
| EMERALD ADVISERS, LLC | 108,082 | $19,740 |
| AQR CAPITAL MANAGEMENT LLC | 103,418 | $18,888 |
| CANADA PENSION PLAN INVESTMENT BOARD | 103,200 | $18,848 |
| DnB Asset Management AS | 101,102 | $18,465 |
| AMERIPRISE FINANCIAL INC | 99,916 | $18,249 |
| DEUTSCHE BANK AG\ | 98,257 | $17,946 |
| abrdn plc | 97,413 | $17,792 |
| ROYCE & ASSOCIATES LP | 94,017 | $17,171 |
| Nicholas Investment Partners, LP | 91,564 | $16,723 |
| M&G PLC | 90,328 | $16,530 |
| WELLS FARGO & COMPANY/MN | 89,661 | $16,376 |
| FEDERATED HERMES, INC. | 87,280 | $15,941 |
| UBS ASSET MANAGEMENT AMERICAS INC | 87,249 | $15,935 |
| Granite Investment Partners, LLC | 84,894 | $15,505 |
| Cannell & Spears LLC | 84,154 | $15,370 |
| BARCLAYS PLC | 76,853 | $14,036 |
| Cormorant Asset Management, LP | 75,000 | $13,698 |
| IRIDIAN ASSET MANAGEMENT LLC/CT | 73,783 | $13,476 |
| Summit Financial, LLC | 70,628 | $12,899 |
| NEUBERGER BERMAN GROUP LLC | 69,483 | $12,690 |
| Swiss National Bank | 68,900 | $12,584 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 68,858 | $12,576 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 67,608 | $12,348 |
| AXIOM INVESTORS LLC /DE | 63,390 | $11,578 |
| IFP Advisors, Inc | 62,448 | $11,406 |
| Walleye Capital LLC | 60,100 | $10,977 |
| Privium Fund Management B.V. | 56,878 | $10,388 |
| Edgestream Partners, L.P. | 56,364 | $10,294 |
| HighTower Advisors, LLC | 55,972 | $10,223 |
| Atika Capital Management LLC | 55,500 | $10,137 |
| ALLIANCEBERNSTEIN L.P. | 53,140 | $9,705 |
| RHUMBLINE ADVISERS | 52,233 | $9,540 |
| Trexquant Investment LP | 49,136 | $8,974 |
| BALDWIN BROTHERS LLC/MA | 48,570 | $8,871 |
| SEI INVESTMENTS CO | 47,600 | $8,694 |
| Bridgewater Associates, LP | 47,444 | $8,665 |
| BLAIR WILLIAM & CO/IL | 46,840 | $8,555 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 46,633 | $8,517 |
| 292 other institutions | 2,394,577 | $397,399 |