AXSOME THERAPEUTICS INC

Ticker: AXSM CUSIP: 05464T104 Class: Common Stock

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 610,970 Value ($000) $25,288 Avg Close $31.00 Range $21.85 - $41.95

Q4 2021

Shares 610,970 Value ($000) $23,082 Avg Close $36.79 Range $29.60 - $44.83

Q3 2021

Shares 539,057 Value ($000) $17,767 Avg Close $38.97 Range $19.38 - $68.74

Q2 2021

Shares 539,057 Value ($000) $36,365 Avg Close $60.01 Range $50.05 - $74.10

Q1 2021

Shares 628,414 Value ($000) $35,581 Avg Close $70.34 Range $55.30 - $82.98

Q4 2020

Shares 778,834 Value ($000) $63,452 Avg Close $74.78 Range $65.00 - $87.24

Q3 2020

Shares 959,757 Value ($000) $68,383 Avg Close $77.92 Range $65.25 - $90.00

Q2 2020

Shares 1,009,757 Value ($000) $83,083 Avg Close $76.97 Range $49.12 - $109.53

Q1 2020

Shares 889,757 Value ($000) $52,344 Avg Close $81.48 Range $35.44 - $104.79

Q4 2019

Shares 829,757 Value ($000) $85,764 Avg Close $40.39 Range $13.64 - $109.94

Q3 2019

Shares 772,286 Value ($000) $15,631 Avg Close $25.70 Range $20.10 - $30.50

Q2 2019

Shares 772,286 Value ($000) $19,886 Avg Close $20.04 Range $12.76 - $26.45

Q1 2019

Shares 1,200,000 Value ($000) $17,076 Avg Close $9.29 Range $2.52 - $16.80

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	610,970	$25,288	$31.00	$21.85 - $41.95
Q4 2021	610,970	$23,082	$36.79	$29.60 - $44.83
Q3 2021	539,057	$17,767	$38.97	$19.38 - $68.74
Q2 2021	539,057	$36,365	$60.01	$50.05 - $74.10
Q1 2021	628,414	$35,581	$70.34	$55.30 - $82.98
Q4 2020	778,834	$63,452	$74.78	$65.00 - $87.24
Q3 2020	959,757	$68,383	$77.92	$65.25 - $90.00
Q2 2020	1,009,757	$83,083	$76.97	$49.12 - $109.53
Q1 2020	889,757	$52,344	$81.48	$35.44 - $104.79
Q4 2019	829,757	$85,764	$40.39	$13.64 - $109.94
Q3 2019	772,286	$15,631	$25.70	$20.10 - $30.50
Q2 2019	772,286	$19,886	$20.04	$12.76 - $26.45
Q1 2019	1,200,000	$17,076	$9.29	$2.52 - $16.80