AXSOME THERAPEUTICS INC

Ticker: AXSM CUSIP: 05464T104 Class: Common Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 7,650 Value ($000) $1,397 Avg Close $139.61 Range $117.30 - $184.40

Q2 2025

Shares 2,228 Value ($000) $233 Avg Close $105.89 Range $86.99 - $120.00

Q1 2024

Shares 2,938 Value ($000) $234 Avg Close $83.94 Range $68.59 - $98.40

Q4 2019

Shares 2,957 Value ($000) $306 Avg Close $40.39 Range $13.64 - $109.94

Q1 2018

Shares 20,126 Value ($000) $49 Avg Close $2.99 Range $2.05 - $5.76

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	7,650	$1,397	$139.61	$117.30 - $184.40
Q2 2025	2,228	$233	$105.89	$86.99 - $120.00
Q1 2024	2,938	$234	$83.94	$68.59 - $98.40
Q4 2019	2,957	$306	$40.39	$13.64 - $109.94
Q1 2018	20,126	$49	$2.99	$2.05 - $5.76