| BAKER BROS. ADVISORS LP | 8,799,053 | $2,673,240 |
| Capital International Investors | 5,113,866 | $1,553,909 |
| PRIMECAP MANAGEMENT CO/CA/ | 4,980,581 | $1,513,150 |
| FMR LLC | 3,992,627 | $1,213,000 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,372,679 | $417 |
| HHLR ADVISORS, LTD. | 1,034,306 | $314,233 |
| Temasek Holdings (Private) Ltd | 919,587 | $279,380 |
| BlackRock, Inc. | 676,210 | $205,439 |
| CITADEL ADVISORS LLC | 533,517 | $162,088 |
| Siren, L.L.C. | 500,000 | $151,905 |
| MORGAN STANLEY | 437,661 | $132,966 |
| BANK OF AMERICA CORP /DE/ | 378,832 | $115,093 |
| Capital International, Inc./CA/ | 307,660 | $93,470 |
| Baird Financial Group, Inc. | 304,339 | $92,461 |
| Man Group plc | 248,514 | $75,501 |
| Candriam S.C.A. | 197,261 | $59,932 |
| Nuveen, LLC | 194,124 | $58,977 |
| BNP PARIBAS ARBITRAGE, SA | 193,951 | $58,924 |
| Artisan Partners Limited Partnership | 165,241 | $50,202 |
| CAPITAL INTERNATIONAL SARL | 152,515 | $46,336 |
| MARSHALL WACE, LLP | 152,296 | $46,269 |
| UBS Group AG | 152,087 | $46,206 |
| GOLDMAN SACHS GROUP INC | 148,714 | $45,181 |
| M&G PLC | 129,791 | $39,456 |
| FIRST TRUST ADVISORS LP | 125,825 | $38,227 |
| Jain Global LLC | 97,335 | $29,571 |
| Qube Research & Technologies Ltd | 94,848 | $28,816 |
| FRANKLIN RESOURCES INC | 94,594 | $28,739 |
| VAN ECK ASSOCIATES CORP | 90,010 | $27 |
| JENNISON ASSOCIATES LLC | 76,438 | $23,223 |
| Patient Square Capital LP | 69,312 | $21,058 |
| Squarepoint Ops LLC | 68,900 | $20,933 |
| ROYAL BANK OF CANADA | 67,992 | $20,656 |
| CAPITAL INTERNATIONAL LTD /CA/ | 67,722 | $20,575 |
| Woodline Partners LP | 66,985 | $20,351 |
| DEUTSCHE BANK AG\ | 60,656 | $18,428 |
| ENVESTNET ASSET MANAGEMENT INC | 56,366 | $17,125 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 56,326 | $17,112 |
| Legal & General Group Plc | 54,185 | $16,462 |
| WELLS FARGO & COMPANY/MN | 51,494 | $15,644 |
| DIMENSIONAL FUND ADVISORS LP | 49,064 | $14,908 |
| LAZARD ASSET MANAGEMENT LLC | 48,221 | $14,650 |
| Engineers Gate Manager LP | 47,864 | $14,542 |
| BARINGS LLC | 42,815 | $13,008 |
| Mirae Asset Global Investments Co., Ltd. | 42,207 | $12,823 |
| Capital Group Private Client Services, Inc. | 41,783 | $12,694 |
| NORTHERN TRUST CORP | 40,629 | $12,343 |
| HealthInvest Partners AB | 40,432 | $12,284 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 39,833 | $12,138 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 36,539 | $11,101 |
| BNP Paribas Investment Partners S.A. | 34,065 | $10 |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 33,020 | $10,032 |
| PANAGORA ASSET MANAGEMENT INC | 32,941 | $10,008 |
| ABN AMRO INVESTMENT SOLUTIONS | 32,076 | $9,745 |
| MILLENNIUM MANAGEMENT LLC | 31,451 | $9,555 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 31,099 | $9,448 |
| NOMURA HOLDINGS INC | 31,062 | $9,437 |
| MACKENZIE FINANCIAL CORP | 30,859 | $9,385 |
| OPPENHEIMER ASSET MANAGEMENT INC. | 30,089 | $9,141 |
| Fiera Capital Corp | 29,900 | $9,084 |
| Slow Capital, Inc. | 27,301 | $8,294 |
| GEODE CAPITAL MANAGEMENT, LLC | 26,252 | $7,976 |
| ASSETMARK, INC | 24,814 | $7,539 |
| BARCLAYS PLC | 24,801 | $7,535 |
| ExodusPoint Capital Management, LP | 24,584 | $7,469 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 23,213 | $7,052 |
| AIA Group Ltd | 22,647 | $6,880 |
| Erste Asset Management GmbH | 21,900 | $6,796 |
| Russell Investments Group, Ltd. | 21,085 | $6,406 |
| Asset Management One Co., Ltd. | 19,998 | $6,205 |
| WELLINGTON MANAGEMENT GROUP LLP | 17,908 | $5,441 |
| RAYMOND JAMES FINANCIAL INC | 17,555 | $5,333 |
| TD Asset Management Inc | 15,752 | $4,786 |
| Nan Fung Group Holdings Ltd | 15,722 | $4,777 |
| CAPITAL GROUP INVESTMENT MANAGEMENT PTE. LTD. | 14,710 | $4,469 |
| Invesco Ltd. | 14,123 | $4,291 |
| DekaBank Deutsche Girozentrale | 13,600 | $2 |
| AMERICAN CENTURY COMPANIES INC | 12,338 | $3,748 |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,654 | $3,541 |
| Quadrature Capital Ltd | 11,334 | $3,443 |
| STIFEL FINANCIAL CORP | 10,967 | $3,332 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 10,692 | $3,248 |
| XTX Topco Ltd | 9,586 | $2,912 |
| Creative Planning | 9,266 | $2,815 |
| Y-Intercept (Hong Kong) Ltd | 9,161 | $2,783 |
| GUGGENHEIM CAPITAL LLC | 9,148 | $2,779 |
| KBC Group NV | 8,986 | $3 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,846 | $2,696 |
| TWO SIGMA INVESTMENTS, LP | 8,400 | $2,552 |
| BANK OF MONTREAL /CAN/ | 8,386 | $2,548 |
| STATE STREET CORP | 8,271 | $2,513 |
| Crossmark Global Holdings, Inc. | 8,214 | $2,495 |
| NEOS Investment Management LLC | 8,187 | $2,487 |
| Generali Investments, Management Co LLC | 8,000 | $184 |
| Long Corridor Asset Management Ltd | 7,731 | $2,349 |
| DIADEMA PARTNERS LP | 7,500 | $173 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 7,495 | $2,277 |
| JPMORGAN CHASE & CO | 7,445 | $2,262 |
| Quantinno Capital Management LP | 6,690 | $2,032 |
| SEI INVESTMENTS CO | 6,657 | $2,022 |
| 183 other institutions | 249,654 | $74,036 |