| Darwin Global Management, Ltd. | 3,027,704 | $486,915 |
| RTW INVESTMENTS, LP | 715,332 | $114,425 |
| MILLENNIUM MANAGEMENT LLC | 558,882 | $89,399 |
| RA CAPITAL MANAGEMENT, L.P. | 432,484 | $69,180 |
| PERCEPTIVE ADVISORS LLC | 414,239 | $66,262 |
| EVENTIDE ASSET MANAGEMENT, LLC | 383,091 | $61,279 |
| Point72 Asset Management, L.P. | 284,437 | $45,499 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 233,813 | $37,401 |
| MARSHALL WACE, LLP | 192,700 | $30,824 |
| UBS Group AG | 128,752 | $20,595 |
| MPM BioImpact LLC | 87,760 | $14,038 |
| Holocene Advisors, LP | 84,067 | $13,447 |
| FRED ALGER MANAGEMENT, LLC | 79,394 | $12,700 |
| Western Standard LLC | 60,026 | $9,602 |
| GOLDMAN SACHS GROUP INC | 44,599 | $7,134 |
| Soleus Capital Management, L.P. | 40,354 | $6,455 |
| ADAR1 Capital Management, LLC | 39,839 | $6,373 |
| JANE STREET GROUP, LLC | 32,318 | $5,170 |
| MORGAN STANLEY | 28,013 | $4,481 |
| Squadron Capital Management LLC | 26,000 | $4,159 |
| Quadrature Capital Ltd | 24,832 | $3,972 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 24,703 | $3,951 |
| Affinity Asset Advisors, LLC | 20,000 | $3,199 |
| PFM Health Sciences, LP | 19,823 | $3,171 |
| Woodline Partners LP | 18,041 | $2,886 |
| Artia Global Partners LP | 17,989 | $2,878 |
| STATE STREET CORP | 15,740 | $2,518 |
| BANK OF MONTREAL /CAN/ | 15,538 | $2,499 |
| Exome Asset Management LLC | 14,328 | $2,292 |
| AMERIPRISE FINANCIAL INC | 13,221 | $2,115 |
| BOOTHBAY FUND MANAGEMENT, LLC | 11,897 | $1,903 |
| GEODE CAPITAL MANAGEMENT, LLC | 10,445 | $1,671 |
| STEMPOINT CAPITAL LP | 9,163 | $1,466 |
| Seven Fleet Capital Management LP | 9,161 | $1,465 |
| HRT FINANCIAL LP | 8,164 | $1 |
| WELLINGTON MANAGEMENT GROUP LLP | 6,198 | $991 |
| CITADEL ADVISORS LLC | 5,055 | $809 |
| SmartHarvest Portfolios, LLC | 4,184 | $669 |
| BARCLAYS PLC | 4,176 | $668 |
| High Net Worth Advisory Group LLC | 3,500 | $560 |
| PSP Research LLC | 3,443 | $551 |
| Y-Intercept (Hong Kong) Ltd | 3,152 | $504 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 3,119 | $499 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 3,049 | $488 |
| SG Americas Securities, LLC | 2,755 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 2,448 | $392 |
| Yeomans Consulting Group, Inc. | 2,399 | $384 |
| CITIGROUP INC | 2,137 | $342 |
| ROYAL BANK OF CANADA | 2,092 | $334 |
| Virtus Investment Advisers, LLC | 1,882 | $301 |
| BANK OF AMERICA CORP /DE/ | 1,852 | $296 |
| GAMMA Investing LLC | 1,779 | $285 |
| Brooklyn Investment Group | 1,739 | $287 |
| EverSource Wealth Advisors, LLC | 1,598 | $256 |
| GSA CAPITAL PARTNERS LLP | 1,463 | $0 |
| Independent Advisor Alliance | 1,319 | $211 |
| Persistent Asset Partners Ltd | 673 | $108 |
| Mirae Asset Global Investments Co., Ltd. | 645 | $103 |
| Caitong International Asset Management Co., Ltd | 549 | $88 |
| China Universal Asset Management Co., Ltd. | 500 | $80 |
| OSAIC HOLDINGS, INC. | 195 | $31 |
| Farther Finance Advisors, LLC | 101 | $16 |
| WELLS FARGO & COMPANY/MN | 100 | $16 |
| TD Waterhouse Canada Inc. | 70 | $11 |
| SBI Securities Co., Ltd. | 50 | $8 |
| Rossby Financial, LCC | 13 | $2 |
| JONES FINANCIAL COMPANIES LLLP | 6 | $1 |
| JPMORGAN CHASE & CO | 3 | $0 |