| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,548,351 | $155,556 |
| JANUS HENDERSON GROUP PLC | 2,911,688 | $39,293 |
| FRANKLIN RESOURCES INC | 2,197,305 | $29,598 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,120,672 | $28,565 |
| RA CAPITAL MANAGEMENT, L.P. | 1,850,000 | $24,920 |
| VANGUARD GROUP INC | 1,174,758 | $15,824 |
| Nantahala Capital Management, LLC | 1,038,371 | $13,987 |
| BlackRock, Inc. | 992,347 | $13,367 |
| INFINITUM ASSET MANAGEMENT, LLC | 898,871 | $12,108 |
| Siren, L.L.C. | 775,000 | $10,439 |
| Alyeska Investment Group, L.P. | 750,000 | $10,103 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 731,717 | $9,856 |
| BALYASNY ASSET MANAGEMENT L.P. | 651,558 | $8,776 |
| MILLENNIUM MANAGEMENT LLC | 613,160 | $8,259 |
| GEODE CAPITAL MANAGEMENT, LLC | 453,375 | $6,109 |
| Longaeva Partners L.P. | 290,000 | $3,906 |
| AWM Investment Company, Inc. | 282,977 | $3,812 |
| AMERIPRISE FINANCIAL INC | 280,727 | $3,781 |
| Schonfeld Strategic Advisors LLC | 262,205 | $3,532 |
| STATE STREET CORP | 245,051 | $3,301 |
| MYDA Advisors LLC | 225,000 | $3,031 |
| GOLDMAN SACHS GROUP INC | 174,041 | $2,344 |
| Simplify Asset Management Inc. | 151,163 | $2,036 |
| Burkehill Global Management, LP | 150,000 | $2,021 |
| NORTHERN TRUST CORP | 126,160 | $1,699 |
| Woodline Partners LP | 100,704 | $1,356 |
| UBS Group AG | 98,347 | $1,325 |
| Lion Point Capital, LP | 62,000 | $835 |
| MORGAN STANLEY | 58,812 | $792 |
| Empery Asset Management, LP | 55,440 | $747 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,274 | $610 |
| MARSHALL WACE, LLP | 35,688 | $481 |
| Bank of New York Mellon Corp | 31,612 | $426 |
| Quadrature Capital Ltd | 31,481 | $424 |
| BARCLAYS PLC | 23,211 | $313 |
| Persistent Asset Partners Ltd | 20,753 | $280 |
| Nuveen, LLC | 18,779 | $253 |
| RHUMBLINE ADVISERS | 17,668 | $238 |
| CITADEL ADVISORS LLC | 17,580 | $237 |
| WELLS FARGO & COMPANY/MN | 16,262 | $219 |
| Squarepoint Ops LLC | 15,045 | $203 |
| HRT FINANCIAL LP | 13,288 | $0 |
| JANE STREET GROUP, LLC | 12,425 | $167 |
| DEUTSCHE BANK AG\ | 12,307 | $166 |
| BANK OF AMERICA CORP /DE/ | 12,125 | $163 |
| MetLife Investment Management, LLC | 9,397 | $127 |
| SG Americas Securities, LLC | 8,232 | $0 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,902 | $93 |
| GAMMA Investing LLC | 6,725 | $91 |
| Russell Investments Group, Ltd. | 6,218 | $84 |
| JPMORGAN CHASE & CO | 6,028 | $81 |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,327 | $58 |
| BNP PARIBAS ARBITRAGE, SA | 4,059 | $55 |
| Truvestments Capital LLC | 3,834 | $52 |
| Police & Firemen's Retirement System of New Jersey | 3,225 | $43 |
| ROYAL BANK OF CANADA | 2,122 | $29 |
| Legal & General Group Plc | 1,532 | $21 |
| Ameritas Investment Partners, Inc. | 1,477 | $20 |
| FMR LLC | 1,311 | $18 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 915 | $12 |
| Tower Research Capital LLC (TRC) | 723 | $10 |
| CITIGROUP INC | 544 | $7 |
| AMALGAMATED BANK | 467 | $0 |
| US BANCORP \DE\ | 202 | $3 |
| QUADRANT CAPITAL GROUP LLC | 173 | $2 |
| PNC Financial Services Group, Inc. | 147 | $2 |
| Sterling Capital Management LLC | 97 | $1 |
| GROUP ONE TRADING, L.P. | 89 | $1 |
| Parallel Advisors, LLC | 55 | $1 |
| CWM, LLC | 9 | $0 |
| IFP Advisors, Inc | 1 | $0 |
| OSAIC HOLDINGS, INC. | 1 | $0 |