BICYCLE THERAPEUTICS PLC

Ticker: BCYC CUSIP: 088786108 Class: ADR

LOOMIS SAYLES & CO L P's Holding History (CIK: 0000312348)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022
Shares 643,775 Value ($000) $28,249 Avg Close — Range —
Q4 2021
Shares 570,047 Value ($000) $34,698 Avg Close — Range —