| BAKER BROS. ADVISORS LP | 10,885,357 | $77,068 |
| FCPM III SERVICES B.V. | 3,468,430 | $24,556 |
| ARMISTICE CAPITAL, LLC | 3,236,000 | $22,911 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 3,016,026 | $21,353 |
| Siren, L.L.C. | 2,012,752 | $14,250 |
| ACADIAN ASSET MANAGEMENT LLC | 1,671,258 | $12 |
| Long Focus Capital Management, LLC | 1,633,091 | $11,562 |
| GSK plc | 1,529,561 | $10,829 |
| Candriam S.C.A. | 1,192,279 | $8,442 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,171,787 | $8 |
| PRINCIPAL FINANCIAL GROUP INC | 1,148,272 | $8,130 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 584,770 | $3,976 |
| BNP Paribas Investment Partners S.A. | 568,225 | $4 |
| RENAISSANCE TECHNOLOGIES LLC | 566,600 | $4,012 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 476,976 | $3,377 |
| MORGAN STANLEY | 465,222 | $3,294 |
| Birchview Capital, LP | 462,700 | $3,276 |
| BlackRock, Inc. | 332,889 | $2,357 |
| MILLENNIUM MANAGEMENT LLC | 326,626 | $2,313 |
| Jefferies Financial Group Inc. | 297,247 | $2,105 |
| MOORE CAPITAL MANAGEMENT, LP | 275,000 | $1,947 |
| CITADEL ADVISORS LLC | 271,383 | $1,921 |
| Palo Alto Investors LP | 221,071 | $1,565 |
| PINNACLE ASSOCIATES LTD | 190,480 | $1,349 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 184,603 | $1,307 |
| Eversept Partners, LP | 178,915 | $1,267 |
| FLAX POND CAPITAL, LLC | 173,633 | $1,229 |
| TD Asset Management Inc | 147,992 | $1,048 |
| TWO SIGMA ADVISERS, LP | 146,100 | $1,034 |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 134,689 | $954 |
| TWO SIGMA INVESTMENTS, LP | 132,032 | $935 |
| Rangeley Capital, LLC | 132,000 | $935 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 127,863 | $869 |
| Walleye Capital LLC | 111,659 | $791 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 108,423 | $768 |
| BANK OF AMERICA CORP /DE/ | 96,401 | $683 |
| MONIMUS CAPITAL MANAGEMENT, LP | 93,840 | $664 |
| Marex Group plc | 78,406 | $555 |
| Point72 Asset Management, L.P. | 76,779 | $544 |
| STATE STREET CORP | 70,178 | $497 |
| Nan Fung Group Holdings Ltd | 68,943 | $488 |
| DAFNA Capital Management LLC | 64,492 | $457 |
| JANE STREET GROUP, LLC | 63,190 | $447 |
| State of Tennessee, Department of Treasury | 61,153 | $393 |
| SEI INVESTMENTS CO | 49,056 | $347 |
| XTX Topco Ltd | 47,674 | $338 |
| Quadrature Capital Ltd | 46,728 | $331 |
| Man Group plc | 42,860 | $303 |
| ALPS ADVISORS INC | 40,995 | $290 |
| HARBOR CAPITAL ADVISORS, INC. | 40,486 | $0 |
| MARSHALL WACE, LLP | 38,795 | $275 |
| Virtus Investment Advisers, LLC | 35,709 | $253 |
| Jump Financial, LLC | 31,000 | $219 |
| DekaBank Deutsche Girozentrale | 30,000 | $1 |
| WOODSTOCK CORP | 29,146 | $206 |
| UBS Group AG | 25,676 | $182 |
| GEODE CAPITAL MANAGEMENT, LLC | 25,129 | $178 |
| GOLDMAN SACHS GROUP INC | 24,732 | $175 |
| Engineers Gate Manager LP | 24,047 | $170 |
| D. E. Shaw & Co., Inc. | 21,548 | $153 |
| State of New Jersey Common Pension Fund D | 20,105 | $142 |
| SIMPLEX TRADING, LLC | 19,986 | $142 |
| FOX RUN MANAGEMENT, L.L.C. | 19,771 | $140 |
| Aquatic Capital Management LLC | 18,817 | $133 |
| JPMORGAN CHASE & CO | 18,355 | $130 |
| PORTLAND INVESTMENT COUNSEL INC. | 15,000 | $106 |
| Federation des caisses Desjardins du Quebec | 14,302 | $101 |
| PNC Financial Services Group, Inc. | 14,138 | $100 |
| Erste Asset Management GmbH | 14,000 | $95 |
| HORIZON KINETICS ASSET MANAGEMENT LLC | 13,792 | $98 |
| Forefront Analytics, LLC | 13,371 | $95 |
| Cerity Partners LLC | 13,350 | $95 |
| Vanguard Personalized Indexing Management, LLC | 12,776 | $90 |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 12,600 | $89 |
| RAYMOND JAMES FINANCIAL INC | 12,336 | $87 |
| Crossmark Global Holdings, Inc. | 11,399 | $81 |
| RHUMBLINE ADVISERS | 11,171 | $79 |
| ROYAL BANK OF CANADA | 10,682 | $76 |
| Brooklyn Investment Group | 10,216 | $69 |
| COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 10,116 | $72 |
| Invesco Ltd. | 10,092 | $71 |
| Vontobel Holding Ltd. | 10,000 | $71 |
| Pinnacle Wealth Management Advisory Group, LLC | 10,000 | $71 |
| Legal & General Group Plc | 9,054 | $64 |
| China Universal Asset Management Co., Ltd. | 7,540 | $53 |
| FNY Investment Advisers, LLC | 7,486 | $0 |
| Clearstead Advisors, LLC | 4,655 | $33 |
| NATIXIS | 4,645 | $32 |
| ASSETMARK, INC | 3,628 | $26 |
| Mirae Asset Global Investments Co., Ltd. | 2,248 | $16 |
| Tower Research Capital LLC (TRC) | 1,668 | $12 |
| GAMMA Investing LLC | 1,386 | $10 |
| CITIGROUP INC | 1,291 | $9 |
| BNP PARIBAS ARBITRAGE, SA | 1,116 | $8 |
| GF FUND MANAGEMENT CO. LTD. | 909 | $6 |
| BARCLAYS PLC | 562 | $4 |
| HighMark Wealth Management LLC | 435 | $3 |
| FMR LLC | 316 | $2 |
| JONES FINANCIAL COMPANIES LLLP | 250 | $2 |
| Farther Finance Advisors, LLC | 218 | $2 |
| 8 other institutions | 523 | $3 |