BICYCLE THERAPEUTICS PLC

Ticker: BCYC CUSIP: 088786108 Class: ADR

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 132,032 Value ($000) $935 Avg Close — Range —
Q3 2025
Shares 184,537 Value ($000) $1,428 Avg Close — Range —
Q2 2025
Shares 56,198 Value ($000) $391 Avg Close — Range —
Q2 2024
Shares 26,583 Value ($000) $538 Avg Close — Range —
Q1 2024
Shares 28,585 Value ($000) $712 Avg Close — Range —
Q4 2023
Shares 103,628 Value ($000) $1,874 Avg Close — Range —
Q3 2023
Shares 22,930 Value ($000) $461 Avg Close — Range —
Q2 2023
Shares 52,626 Value ($000) $1,343 Avg Close — Range —
Q1 2023
Shares 160,576 Value ($000) $3,415 Avg Close — Range —
Q3 2022
Shares 49,500 Value ($000) $1,151 Avg Close — Range —
Q2 2022
Shares 380,654 Value ($000) $6,387 Avg Close — Range —
Q1 2022
Shares 177,322 Value ($000) $7,781 Avg Close — Range —
Q4 2021
Shares 151,361 Value ($000) $9,213 Avg Close — Range —
Q3 2021
Shares 92,192 Value ($000) $3,834 Avg Close — Range —
Q4 2020
Shares 20,399 Value ($000) $366 Avg Close — Range —