BICYCLE THERAPEUTICS PLC

Ticker: BCYC CUSIP: 088786108 Class: ADR

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025
Shares 146,100 Value ($000) $1,034 Avg Close — Range —
Q3 2025
Shares 156,700 Value ($000) $1,213 Avg Close — Range —
Q2 2025
Shares 70,200 Value ($000) $488 Avg Close — Range —
Q3 2024
Shares 11,300 Value ($000) $256 Avg Close — Range —
Q2 2024
Shares 30,900 Value ($000) $625 Avg Close — Range —
Q1 2024
Shares 46,600 Value ($000) $1,160 Avg Close — Range —
Q4 2023
Shares 62,207 Value ($000) $1,125 Avg Close — Range —
Q3 2023
Shares 70,700 Value ($000) $1,420 Avg Close — Range —
Q2 2023
Shares 139,400 Value ($000) $3,557 Avg Close — Range —
Q1 2023
Shares 187,900 Value ($000) $3,997 Avg Close — Range —
Q4 2022
Shares 161,800 Value ($000) $4,789 Avg Close — Range —
Q3 2022
Shares 262,700 Value ($000) $6,110 Avg Close — Range —
Q2 2022
Shares 415,200 Value ($000) $6,967 Avg Close — Range —
Q1 2022
Shares 128,800 Value ($000) $5,652 Avg Close — Range —
Q4 2021
Shares 97,200 Value ($000) $5,917 Avg Close — Range —
Q3 2021
Shares 46,700 Value ($000) $1,942 Avg Close — Range —