BIOCRYST PHARMACEUTICALS INC

Ticker: BCRX CUSIP: 09058V103 Class: Common Stock

RA CAPITAL MANAGEMENT, L.P.'s Holding History (CIK: 0001346824)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 15,827,186 Value ($000) $123,452 Avg Close $7.23 Range $6.00 - $8.17

Q1 2019

Shares 8,659,983 Value ($000) $70,492 Avg Close $8.56 Range $7.10 - $9.95

Q4 2018

Shares 10,660,349 Value ($000) $86,029 Avg Close $7.78 Range $6.43 - $9.71

Q3 2018

Shares 9,234,692 Value ($000) $70,461 Avg Close $6.72 Range $5.41 - $8.13

Q2 2018

Shares 6,984,692 Value ($000) $40,022 Avg Close $5.50 Range $4.53 - $6.67

Q1 2018

Shares 6,984,692 Value ($000) $33,317 Avg Close $5.14 Range $4.25 - $5.92

Q4 2017

Shares 6,984,692 Value ($000) $34,295 Avg Close $4.84 Range $4.12 - $5.35

Q3 2017

Shares 6,984,692 Value ($000) $36,600 Avg Close $5.12 Range $3.95 - $6.22

Q2 2017

Shares 5,162,242 Value ($000) $28,702 Avg Close $6.09 Range $5.02 - $8.80

Q1 2017

Shares 3,489,795 Value ($000) $29,314 Avg Close $6.96 Range $4.20 - $9.25

Q4 2016

Shares 2,989,795 Value ($000) $18,925 Avg Close $5.20 Range $3.75 - $7.56

Q3 2016

Shares 2,989,795 Value ($000) $13,185 Avg Close $3.99 Range $2.82 - $5.80

Q2 2016

Shares 2,989,795 Value ($000) $8,491 Avg Close $3.10 Range $2.49 - $4.03

Q1 2016

Shares 2,989,795 Value ($000) $8,461 Avg Close $4.43 Range $1.63 - $10.24

Q4 2015

Shares 3,094,064 Value ($000) $31,931 Avg Close $9.94 Range $8.01 - $12.88

Q3 2015

Shares 1,196,603 Value ($000) $13,641 Avg Close $13.34 Range $10.26 - $16.83

Q2 2015

Shares 2,605,361 Value ($000) $38,898 Avg Close $11.37 Range $8.50 - $16.43

Q1 2015

Shares 6,926,617 Value ($000) $62,547 Avg Close $10.35 Range $7.85 - $12.71

Q4 2014

Shares 7,050,356 Value ($000) $85,732 Avg Close $11.05 Range $9.02 - $13.28

Q3 2014

Shares 7,069,159 Value ($000) $69,136 Avg Close $12.26 Range $9.78 - $14.62

Q2 2014

Shares 3,198,529 Value ($000) $40,781 Avg Close $9.73 Range $7.29 - $12.86

Q1 2014

Shares 4,347,456 Value ($000) $45,996 Avg Close $10.66 Range $7.46 - $13.33

Q4 2013

Shares 4,347,456 Value ($000) $33,041 Avg Close $6.33 Range $4.55 - $7.84

Q3 2013

Shares 5,844,700 Value ($000) $42,549 Avg Close $5.07 Range $1.51 - $7.59

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	15,827,186	$123,452	$7.23	$6.00 - $8.17
Q1 2019	8,659,983	$70,492	$8.56	$7.10 - $9.95
Q4 2018	10,660,349	$86,029	$7.78	$6.43 - $9.71
Q3 2018	9,234,692	$70,461	$6.72	$5.41 - $8.13
Q2 2018	6,984,692	$40,022	$5.50	$4.53 - $6.67
Q1 2018	6,984,692	$33,317	$5.14	$4.25 - $5.92
Q4 2017	6,984,692	$34,295	$4.84	$4.12 - $5.35
Q3 2017	6,984,692	$36,600	$5.12	$3.95 - $6.22
Q2 2017	5,162,242	$28,702	$6.09	$5.02 - $8.80
Q1 2017	3,489,795	$29,314	$6.96	$4.20 - $9.25
Q4 2016	2,989,795	$18,925	$5.20	$3.75 - $7.56
Q3 2016	2,989,795	$13,185	$3.99	$2.82 - $5.80
Q2 2016	2,989,795	$8,491	$3.10	$2.49 - $4.03
Q1 2016	2,989,795	$8,461	$4.43	$1.63 - $10.24
Q4 2015	3,094,064	$31,931	$9.94	$8.01 - $12.88
Q3 2015	1,196,603	$13,641	$13.34	$10.26 - $16.83
Q2 2015	2,605,361	$38,898	$11.37	$8.50 - $16.43
Q1 2015	6,926,617	$62,547	$10.35	$7.85 - $12.71
Q4 2014	7,050,356	$85,732	$11.05	$9.02 - $13.28
Q3 2014	7,069,159	$69,136	$12.26	$9.78 - $14.62
Q2 2014	3,198,529	$40,781	$9.73	$7.29 - $12.86
Q1 2014	4,347,456	$45,996	$10.66	$7.46 - $13.33
Q4 2013	4,347,456	$33,041	$6.33	$4.55 - $7.84
Q3 2013	5,844,700	$42,549	$5.07	$1.51 - $7.59