| VANGUARD GROUP INC | 22,273,375 | $173,732 |
| BlackRock, Inc. | 21,137,791 | $164,875 |
| RA CAPITAL MANAGEMENT, L.P. | 15,827,186 | $123,452 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 14,341,000 | $111,860 |
| STATE STREET CORP | 11,073,211 | $86,371 |
| Kynam Capital Management, LP | 9,366,526 | $73,059 |
| JANUS HENDERSON GROUP PLC | 7,404,386 | $57,791 |
| UBS Group AG | 5,263,914 | $41,059 |
| GEODE CAPITAL MANAGEMENT, LLC | 5,053,786 | $39,427 |
| TWO SIGMA INVESTMENTS, LP | 4,515,317 | $35,219 |
| TWO SIGMA ADVISERS, LP | 4,089,112 | $31,895 |
| Nuveen, LLC | 3,612,366 | $28,176 |
| GOLDMAN SACHS GROUP INC | 3,212,785 | $25,060 |
| PERCEPTIVE ADVISORS LLC | 3,162,529 | $24,668 |
| GW&K Investment Management, LLC | 3,160,924 | $25 |
| Eversept Partners, LP | 2,992,895 | $23,345 |
| BAKER BROS. ADVISORS LP | 2,822,727 | $22,017 |
| BNP PARIBAS ARBITRAGE, SA | 2,542,714 | $19,833 |
| Fisher Asset Management, LLC | 2,467,567 | $19,247 |
| Vestal Point Capital, LP | 2,250,000 | $17,550 |
| Qube Research & Technologies Ltd | 2,164,162 | $16,880 |
| Elmind Capital, LP | 2,150,000 | $16,770 |
| RENAISSANCE TECHNOLOGIES LLC | 2,128,821 | $16,605 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,004,939 | $15,639 |
| RICE HALL JAMES & ASSOCIATES, LLC | 1,904,146 | $14,852 |
| NORTHERN TRUST CORP | 1,856,903 | $14,484 |
| STIFEL FINANCIAL CORP | 1,824,517 | $14,231 |
| MORGAN STANLEY | 1,745,563 | $13,615 |
| ORBIMED ADVISORS LLC | 1,741,800 | $13,586 |
| Squarepoint Ops LLC | 1,659,192 | $12,942 |
| BANK OF AMERICA CORP /DE/ | 1,535,557 | $11,977 |
| Nantahala Capital Management, LLC | 1,356,377 | $10,580 |
| Invesco Ltd. | 1,354,897 | $10,568 |
| CITADEL ADVISORS LLC | 1,298,902 | $10,131 |
| D. E. Shaw & Co., Inc. | 1,247,466 | $9,730 |
| DIMENSIONAL FUND ADVISORS LP | 1,228,852 | $9,585 |
| Point72 Asset Management, L.P. | 1,213,576 | $9,466 |
| JUPITER ASSET MANAGEMENT LTD | 1,197,619 | $9,341 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,031,488 | $8,046 |
| Hudson Bay Capital Management LP | 1,017,374 | $7,936 |
| abrdn plc | 913,593 | $7,126 |
| Jump Financial, LLC | 910,930 | $7,105 |
| Parkman Healthcare Partners LLC | 900,057 | $7,020 |
| JPMORGAN CHASE & CO | 843,370 | $6,578 |
| SPHERA FUNDS MANAGEMENT LTD. | 837,889 | $6,536 |
| TANG CAPITAL MANAGEMENT LLC | 800,000 | $6,240 |
| Susquehanna Portfolio Strategies, LLC | 778,521 | $6,072 |
| Pictet Asset Management Holding SA | 740,510 | $5,712 |
| BARCLAYS PLC | 726,367 | $5,666 |
| HRT FINANCIAL LP | 716,826 | $6 |
| AQR CAPITAL MANAGEMENT LLC | 704,291 | $5,493 |
| PDT Partners, LLC | 683,416 | $5,331 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 671,693 | $5,239 |
| JANE STREET GROUP, LLC | 649,357 | $5,065 |
| Voya Investment Management LLC | 625,490 | $4,879 |
| Bank of New York Mellon Corp | 607,992 | $4,742 |
| FRANKLIN RESOURCES INC | 570,189 | $4,447 |
| FMR LLC | 560,182 | $4,369 |
| Hillsdale Investment Management Inc. | 559,100 | $4,361 |
| DEUTSCHE BANK AG\ | 491,086 | $3,830 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 449,743 | $3,508 |
| DAFNA Capital Management LLC | 418,255 | $3,262 |
| Man Group plc | 407,850 | $3,181 |
| Swiss National Bank | 394,368 | $3,076 |
| Rafferty Asset Management, LLC | 382,556 | $2,984 |
| UBS ASSET MANAGEMENT AMERICAS INC | 378,853 | $2,955 |
| PRINCIPAL FINANCIAL GROUP INC | 376,568 | $2,937 |
| FIRST TRUST ADVISORS LP | 374,961 | $2,925 |
| Assenagon Asset Management S.A. | 359,580 | $2,805 |
| Connor, Clark & Lunn Investment Management Ltd. | 357,086 | $2,785 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 355,055 | $2,574 |
| STATE OF WISCONSIN INVESTMENT BOARD | 347,190 | $2,708 |
| CANADA PENSION PLAN INVESTMENT BOARD | 327,941 | $2,558 |
| VICTORY CAPITAL MANAGEMENT INC | 325,051 | $2,535 |
| Ishara Investments LP | 300,000 | $2,340 |
| FEDERATED HERMES, INC. | 292,850 | $2,284 |
| ALLIANCEBERNSTEIN L.P. | 278,190 | $2,170 |
| DOLIVER ADVISORS, LP | 274,328 | $2,140 |
| RHUMBLINE ADVISERS | 266,562 | $2,079 |
| HUSSMAN STRATEGIC ADVISORS, INC. | 252,000 | $1,966 |
| Walleye Capital LLC | 251,670 | $1,963 |
| Phocas Financial Corp. | 250,797 | $1,956 |
| Bridgewater Associates, LP | 235,572 | $1,837 |
| WELLS FARGO & COMPANY/MN | 233,639 | $1,822 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 233,354 | $1,820 |
| Russell Investments Group, Ltd. | 229,226 | $1,788 |
| Engineers Gate Manager LP | 224,543 | $1,751 |
| Gotham Asset Management, LLC | 216,946 | $1,692 |
| Legal & General Group Plc | 210,999 | $1,646 |
| Integral Health Asset Management, LLC | 200,000 | $1,560 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 191,847 | $1,496 |
| DIADEMA PARTNERS LP | 190,928 | $1,489 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 177,392 | $1 |
| ROYAL BANK OF CANADA | 161,456 | $1,260 |
| QTR Family Wealth, LLC | 154,062 | $1,009 |
| MACKENZIE FINANCIAL CORP | 150,728 | $1,152 |
| PROFUND ADVISORS LLC | 141,985 | $1,107 |
| Schonfeld Strategic Advisors LLC | 141,449 | $1,103 |
| MILLENNIUM MANAGEMENT LLC | 137,626 | $1,073 |
| RAYMOND JAMES FINANCIAL INC | 131,103 | $1,023 |
| 170 other institutions | 5,221,517 | $36,581 |