BLUEPRINT MEDICINES CORP

CUSIP: 09627Y109 Class: Common Stock

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2020
Shares 109,500 Value ($000) $6,404 Avg Close — Range —
Q4 2019
Shares 106,000 Value ($000) $8,492 Avg Close — Range —
Q3 2019
Shares 42,500 Value ($000) $3,122 Avg Close — Range —