BLUEPRINT MEDICINES CORP

CUSIP: 09627Y109 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2019
Shares 100,000 Value ($000) $8,001 Avg Close — Range —
Q3 2019
Shares 105,000 Value ($000) $7,714 Avg Close — Range —
Q2 2019
Shares 125,000 Value ($000) $11,791 Avg Close — Range —
Q1 2019
Shares 130,000 Value ($000) $10,407 Avg Close — Range —
Q4 2018
Shares 300,000 Value ($000) $16,173 Avg Close — Range —
Q3 2018
Shares 300,000 Value ($000) $23,418 Avg Close — Range —
Q2 2018
Shares 350,000 Value ($000) $22,218 Avg Close — Range —
Q1 2018
Shares 600,000 Value ($000) $55,020 Avg Close — Range —
Q4 2017
Shares 735,000 Value ($000) $55,426 Avg Close — Range —
Q3 2017
Shares 735,000 Value ($000) $51,207 Avg Close — Range —
Q2 2017
Shares 880,000 Value ($000) $44,589 Avg Close — Range —
Q1 2017
Shares 880,000 Value ($000) $35,191 Avg Close — Range —
Q4 2016
Shares 880,000 Value ($000) $24,684 Avg Close — Range —
Q3 2016
Shares 785,000 Value ($000) $23,315 Avg Close — Range —
Q2 2016
Shares 250,000 Value ($000) $5,063 Avg Close — Range —
Q1 2016
Shares 220,000 Value ($000) $3,971 Avg Close — Range —
Q4 2015
Shares 275,000 Value ($000) $7,244 Avg Close — Range —
Q3 2015
Shares 130,000 Value ($000) $2,774 Avg Close — Range —