| Cormorant Asset Management, LP | 17,878,594 | $223,840 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 4,885,446 | $61,166 |
| Omega Fund Management, LLC | 3,289,661 | $41,187 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,907,003 | $36,396 |
| EcoR1 Capital, LLC | 2,823,126 | $35,346 |
| Alphabet Inc. | 2,823,126 | $35,346 |
| Enavate Sciences GP, LLC | 2,626,946 | $32,889 |
| CITADEL ADVISORS LLC | 2,530,324 | $31,680 |
| Paradigm Biocapital Advisors LP | 2,261,749 | $28,317 |
| BlackRock, Inc. | 2,084,837 | $26,102 |
| Novo Holdings A/S | 1,961,317 | $24,556 |
| Laurion Capital Management LP | 1,464,938 | $18,341 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,400,000 | $17,528 |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,082,362 | $13,389 |
| Octagon Capital Advisors LP | 1,043,110 | $13,060 |
| ARMISTICE CAPITAL, LLC | 1,000,000 | $12,520 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 803,134 | $10 |
| VANGUARD GROUP INC | 791,095 | $9,905 |
| Aisling Capital Management LP | 564,625 | $7,069 |
| GEODE CAPITAL MANAGEMENT, LLC | 561,987 | $7,039 |
| Catalio Capital Management, LP | 410,700 | $31,414 |
| Casdin Capital, LLC | 282,312 | $3,535 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 279,046 | $3,494 |
| MILLENNIUM MANAGEMENT LLC | 241,415 | $3,023 |
| FMR LLC | 240,300 | $3,009 |
| HighVista Strategies LLC | 229,263 | $2,870 |
| ADAR1 Capital Management, LLC | 226,248 | $2,833 |
| Ikarian Capital, LLC | 220,231 | $2,757 |
| STATE STREET CORP | 218,278 | $2,733 |
| Sio Capital Management, LLC | 130,628 | $1,635 |
| TD Asset Management Inc | 117,150 | $1,467 |
| Woodline Partners LP | 103,707 | $1,298 |
| MOORE CAPITAL MANAGEMENT, LP | 100,000 | $1,252 |
| GOLDMAN SACHS GROUP INC | 94,651 | $1,185 |
| UBS Group AG | 93,369 | $1,169 |
| STEMPOINT CAPITAL LP | 86,517 | $1,083 |
| RENAISSANCE TECHNOLOGIES LLC | 74,300 | $930 |
| BOOTHBAY FUND MANAGEMENT, LLC | 67,034 | $839 |
| NORTHERN TRUST CORP | 58,034 | $727 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 54,192 | $670 |
| Qube Research & Technologies Ltd | 35,952 | $450 |
| XTX Topco Ltd | 28,633 | $358 |
| BNP PARIBAS ARBITRAGE, SA | 26,472 | $331 |
| BIT Capital GmbH | 25,000 | $313 |
| Point72 Asset Management, L.P. | 23,584 | $295 |
| MORGAN STANLEY | 14,352 | $180 |
| Quadrature Capital Ltd | 12,922 | $162 |
| Squarepoint Ops LLC | 11,515 | $144 |
| Persistent Asset Partners Ltd | 8,585 | $107 |
| CIBC Private Wealth Group, LLC | 5,000 | $63 |
| BANK OF AMERICA CORP /DE/ | 3,990 | $50 |
| Rockefeller Capital Management L.P. | 700 | $9 |
| WELLS FARGO & COMPANY/MN | 300 | $4 |