| JANUS HENDERSON GROUP PLC | 1,155,995 | $90,832 |
| Cormorant Asset Management, LP | 1,059,331 | $82,670 |
| Vivo Capital, LLC | 501,617 | $39,146 |
| PERCEPTIVE ADVISORS LLC | 449,290 | $35,063 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 395,743 | $30,884 |
| BlackRock, Inc. | 394,043 | $30,751 |
| BRAIDWELL LP | 324,358 | $25,313 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 269,641 | $21,043 |
| MPM BioImpact LLC | 230,147 | $17,961 |
| BALYASNY ASSET MANAGEMENT L.P. | 225,412 | $17,591 |
| MILLENNIUM MANAGEMENT LLC | 194,437 | $15,174 |
| Ikarian Capital, LLC | 159,421 | $12,441 |
| MORGAN STANLEY | 132,122 | $10,311 |
| EVENTIDE ASSET MANAGEMENT, LLC | 103,013 | $8,039 |
| STEMPOINT CAPITAL LP | 97,340 | $7,596 |
| ACUTA CAPITAL PARTNERS, LLC | 84,477 | $6,593 |
| Sio Capital Management, LLC | 81,883 | $6,390 |
| STATE STREET CORP | 77,278 | $6,031 |
| GEODE CAPITAL MANAGEMENT, LLC | 63,546 | $4,959 |
| SEVEN GRAND MANAGERS, LLC | 50,000 | $3,902 |
| VANGUARD GROUP INC | 48,576 | $3,791 |
| GOLDMAN SACHS GROUP INC | 48,547 | $3,789 |
| BOOTHBAY FUND MANAGEMENT, LLC | 47,490 | $3,706 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 47,278 | $3,690 |
| Artia Global Partners LP | 33,407 | $2,607 |
| Schonfeld Strategic Advisors LLC | 30,211 | $2,358 |
| Walleye Capital LLC | 25,826 | $2,015 |
| BNP PARIBAS ARBITRAGE, SA | 25,676 | $2,004 |
| NORTHERN TRUST CORP | 25,570 | $1,995 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 21,730 | $1,696 |
| Commodore Capital LP | 18,851 | $1,471 |
| BANK OF AMERICA CORP /DE/ | 15,075 | $1,176 |
| UBS Group AG | 13,813 | $1,078 |
| WELLINGTON MANAGEMENT GROUP LLP | 13,688 | $1,068 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,465 | $973 |
| Bank of New York Mellon Corp | 9,989 | $780 |
| AdvisorShares Investments LLC | 9,944 | $776 |
| BARCLAYS PLC | 9,660 | $754 |
| JANE STREET GROUP, LLC | 9,018 | $704 |
| Nuveen, LLC | 5,987 | $467 |
| RHUMBLINE ADVISERS | 5,936 | $463 |
| LPL Financial LLC | 5,645 | $441 |
| WELLS FARGO & COMPANY/MN | 5,523 | $431 |
| MARSHALL WACE, LLP | 4,600 | $359 |
| DEUTSCHE BANK AG\ | 4,259 | $332 |
| Invesco Ltd. | 4,198 | $328 |
| D. E. Shaw & Co., Inc. | 3,917 | $306 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,781 | $295 |
| ADAR1 Capital Management, LLC | 3,500 | $273 |
| MetLife Investment Management, LLC | 2,918 | $228 |
| Virtu Financial LLC | 2,897 | $0 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,830 | $0 |
| TWO SIGMA INVESTMENTS, LP | 2,601 | $203 |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,600 | $203 |
| JPMORGAN CHASE & CO | 2,516 | $196 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 2,323 | $181 |
| Police & Firemen's Retirement System of New Jersey | 1,505 | $117 |
| FMR LLC | 1,111 | $87 |
| Tower Research Capital LLC (TRC) | 1,082 | $84 |
| Russell Investments Group, Ltd. | 934 | $73 |
| STRS OHIO | 900 | $70 |
| Legal & General Group Plc | 547 | $43 |
| ROYAL BANK OF CANADA | 527 | $40 |
| Ameritas Investment Partners, Inc. | 470 | $37 |
| OSAIC HOLDINGS, INC. | 371 | $29 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 310 | $24 |
| AMALGAMATED BANK | 159 | $0 |
| CITIGROUP INC | 114 | $9 |
| Global Retirement Partners, LLC | 100 | $8 |
| NewEdge Advisors, LLC | 50 | $4 |
| Farther Finance Advisors, LLC | 39 | $3 |
| Sterling Capital Management LLC | 30 | $2 |
| CWM, LLC | 10 | $0 |
| SBI Securities Co., Ltd. | 5 | $0 |