CARA THERAPEUTICS INC

CUSIP: 140755109 Class: Common Stock

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q3 2019
Shares 440,000 Value ($000) $8,043 Avg Close — Range —
Q1 2019
Shares 200,000 Value ($000) $3,924 Avg Close — Range —
Q3 2018
Shares 130,000 Value ($000) $3,113 Avg Close — Range —
Q1 2017
Shares 385,000 Value ($000) $7,080 Avg Close — Range —
Q4 2016
Shares 475,000 Value ($000) $4,413 Avg Close — Range —
Q3 2016
Shares 675,000 Value ($000) $5,636 Avg Close — Range —
Q2 2016
Shares 835,000 Value ($000) $4,016 Avg Close — Range —
Q1 2016
Shares 855,000 Value ($000) $5,318 Avg Close — Range —
Q4 2015
Shares 427,000 Value ($000) $7,199 Avg Close — Range —
Q3 2015
Shares 415,000 Value ($000) $5,930 Avg Close — Range —
Q2 2015
Shares 340,000 Value ($000) $4,131 Avg Close — Range —
Q1 2015
Shares 315,000 Value ($000) $3,166 Avg Close — Range —
Q4 2014
Shares 80,000 Value ($000) $798 Avg Close — Range —