CAREDX INC

Ticker: CDNA CUSIP: 14167L103 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 89,300 Value ($000) $1,682 Avg Close $16.75 Range $13.95 - $20.92

Q2 2025

Shares 156,614 Value ($000) $3,060 Avg Close $17.77 Range $14.09 - $20.39

Q1 2025

Shares 321,906 Value ($000) $5,714 Avg Close $21.54 Range $17.05 - $25.95

Q4 2024

Shares 468,836 Value ($000) $10,038 Avg Close $24.32 Range $20.09 - $32.97

Q3 2024

Shares 312,524 Value ($000) $9,759 Avg Close $24.88 Range $14.09 - $34.84

Q2 2024

Shares 105,980 Value ($000) $1,646 Avg Close $12.09 Range $7.42 - $17.03

Q1 2024

Shares 88,814 Value ($000) $941 Avg Close $10.00 Range $7.83 - $12.83

Q4 2023

Shares 125,161 Value ($000) $1,502 Avg Close $8.19 Range $4.80 - $12.93

Q3 2023

Shares 54,400 Value ($000) $381 Avg Close $9.24 Range $6.87 - $11.80

Q2 2023

Shares 142,000 Value ($000) $1,207 Avg Close $8.34 Range $6.22 - $9.56

Q1 2023

Shares 276,304 Value ($000) $2,525 Avg Close $12.79 Range $8.10 - $18.04

Q4 2022

Shares 232,653 Value ($000) $2,655 Avg Close $14.82 Range $10.68 - $20.71

Q3 2022

Shares 503,454 Value ($000) $8,569 Avg Close $21.46 Range $15.66 - $27.33

Q2 2022

Shares 489,766 Value ($000) $10,520 Avg Close $27.73 Range $19.34 - $40.10

Q1 2022

Shares 293,364 Value ($000) $10,852 Avg Close $38.97 Range $27.87 - $47.82

Q4 2021

Shares 285,380 Value ($000) $12,979 Avg Close $52.20 Range $39.16 - $75.92

Q3 2021

Shares 183,852 Value ($000) $11,651 Avg Close $76.15 Range $58.44 - $92.55

Q2 2021

Shares 41,800 Value ($000) $3,826 Avg Close $79.49 Range $61.55 - $96.88

Q1 2021

Shares 390,082 Value ($000) $26,561 Avg Close $77.64 Range $56.82 - $99.83

Q4 2020

Shares 110,416 Value ($000) $8,000 Avg Close $57.94 Range $38.59 - $79.92

Q3 2020

Shares 246,838 Value ($000) $9,365 Avg Close $33.76 Range $29.86 - $38.67

Q2 2020

Shares 16,700 Value ($000) $592 Avg Close $28.46 Range $18.61 - $35.49

Q3 2019

Shares 102,242 Value ($000) $2,312 Avg Close $27.69 Range $19.53 - $41.27

Q2 2019

Shares 131,031 Value ($000) $4,716 Avg Close $32.01 Range $25.54 - $40.50

Q1 2019

Shares 385,740 Value ($000) $12,159 Avg Close $29.13 Range $21.46 - $39.38

Q4 2018

Shares 230,804 Value ($000) $5,802 Avg Close $25.69 Range $19.11 - $30.80

Q3 2018

Shares 473,545 Value ($000) $13,662 Avg Close $18.71 Range $11.85 - $29.60

Q1 2018

Shares 150,521 Value ($000) $1,200 Avg Close $6.16 Range $4.92 - $8.35

Q4 2017

Shares 48,014 Value ($000) $352 Avg Close $6.23 Range $3.65 - $7.98

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	89,300	$1,682	$16.75	$13.95 - $20.92
Q2 2025	156,614	$3,060	$17.77	$14.09 - $20.39
Q1 2025	321,906	$5,714	$21.54	$17.05 - $25.95
Q4 2024	468,836	$10,038	$24.32	$20.09 - $32.97
Q3 2024	312,524	$9,759	$24.88	$14.09 - $34.84
Q2 2024	105,980	$1,646	$12.09	$7.42 - $17.03
Q1 2024	88,814	$941	$10.00	$7.83 - $12.83
Q4 2023	125,161	$1,502	$8.19	$4.80 - $12.93
Q3 2023	54,400	$381	$9.24	$6.87 - $11.80
Q2 2023	142,000	$1,207	$8.34	$6.22 - $9.56
Q1 2023	276,304	$2,525	$12.79	$8.10 - $18.04
Q4 2022	232,653	$2,655	$14.82	$10.68 - $20.71
Q3 2022	503,454	$8,569	$21.46	$15.66 - $27.33
Q2 2022	489,766	$10,520	$27.73	$19.34 - $40.10
Q1 2022	293,364	$10,852	$38.97	$27.87 - $47.82
Q4 2021	285,380	$12,979	$52.20	$39.16 - $75.92
Q3 2021	183,852	$11,651	$76.15	$58.44 - $92.55
Q2 2021	41,800	$3,826	$79.49	$61.55 - $96.88
Q1 2021	390,082	$26,561	$77.64	$56.82 - $99.83
Q4 2020	110,416	$8,000	$57.94	$38.59 - $79.92
Q3 2020	246,838	$9,365	$33.76	$29.86 - $38.67
Q2 2020	16,700	$592	$28.46	$18.61 - $35.49
Q3 2019	102,242	$2,312	$27.69	$19.53 - $41.27
Q2 2019	131,031	$4,716	$32.01	$25.54 - $40.50
Q1 2019	385,740	$12,159	$29.13	$21.46 - $39.38
Q4 2018	230,804	$5,802	$25.69	$19.11 - $30.80
Q3 2018	473,545	$13,662	$18.71	$11.85 - $29.60
Q1 2018	150,521	$1,200	$6.16	$4.92 - $8.35
Q4 2017	48,014	$352	$6.23	$3.65 - $7.98