| BlackRock, Inc. | 4,650,409 | $87,614 |
| VANGUARD GROUP INC | 3,428,252 | $64,588 |
| BAMCO INC /NY/ | 3,155,180 | $59,444 |
| STATE STREET CORP | 2,737,752 | $51,579 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,191,000 | $41,278 |
| ARK Investment Management LLC | 2,136,403 | $40,250 |
| GAGNON SECURITIES LLC | 1,774,890 | $33,439 |
| BRAIDWELL LP | 1,585,220 | $29,866 |
| Sumitomo Mitsui Trust Holdings, Inc. | 1,446,616 | $27,254 |
| Nikko Asset Management Americas, Inc. | 1,446,616 | $27,254 |
| DIMENSIONAL FUND ADVISORS LP | 1,309,980 | $24,681 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,243,967 | $23,440 |
| RENAISSANCE TECHNOLOGIES LLC | 1,105,198 | $20,822 |
| Chevy Chase Trust Holdings, LLC | 1,081,342 | $20,372 |
| D. E. Shaw & Co., Inc. | 1,038,486 | $19,565 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 948,557 | $17,871 |
| Ophir Asset Management Pty Ltd | 925,433 | $17,435 |
| Boston Partners | 901,929 | $16,994 |
| GOLDMAN SACHS GROUP INC | 811,186 | $15,283 |
| Portolan Capital Management, LLC | 758,775 | $14,295 |
| ArrowMark Colorado Holdings LLC | 758,400 | $14,288 |
| Zweig-DiMenna Associates LLC | 679,000 | $12,792 |
| Connor, Clark & Lunn Investment Management Ltd. | 665,065 | $12,530 |
| CITADEL ADVISORS LLC | 642,762 | $12,110 |
| ROYCE & ASSOCIATES LP | 581,211 | $10,950 |
| First Eagle Investment Management, LLC | 546,722 | $10,300 |
| MORGAN STANLEY | 541,522 | $10,202 |
| Gagnon Advisors, LLC | 532,892 | $10,040 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 525,009 | $9,891 |
| Blue Water Life Science Advisors, LP | 510,000 | $9,608 |
| BNP PARIBAS ARBITRAGE, SA | 487,050 | $9,176 |
| Palo Alto Investors LP | 478,220 | $9,010 |
| NORTHERN TRUST CORP | 449,886 | $8,476 |
| Bellevue Group AG | 431,070 | $8,121 |
| JANE STREET GROUP, LLC | 430,229 | $8,106 |
| Russell Investments Group, Ltd. | 420,225 | $7,917 |
| PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE | 375,000 | $7,065 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 371,409 | $6,997 |
| abrdn plc | 345,308 | $6,506 |
| Nuveen, LLC | 333,898 | $6,291 |
| BANK OF AMERICA CORP /DE/ | 324,825 | $6,120 |
| AQR CAPITAL MANAGEMENT LLC | 303,035 | $5,709 |
| JANUS HENDERSON GROUP PLC | 287,561 | $5,418 |
| Parkman Healthcare Partners LLC | 276,154 | $5,203 |
| Prosight Management, LP | 250,000 | $4,710 |
| Bullseye Asset Management LLC | 235,485 | $4 |
| Man Group plc | 233,171 | $4,393 |
| Legal & General Group Plc | 230,482 | $4,342 |
| FMR LLC | 209,419 | $3,945 |
| FRED ALGER MANAGEMENT, LLC | 174,748 | $3,292 |
| Bank of New York Mellon Corp | 169,910 | $3,201 |
| WELLINGTON MANAGEMENT GROUP LLP | 169,868 | $3,200 |
| BARCLAYS PLC | 164,413 | $3,098 |
| RAYMOND JAMES FINANCIAL INC | 161,991 | $3,052 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 139,439 | $2,627 |
| UBS ASSET MANAGEMENT AMERICAS INC | 125,190 | $2,359 |
| STATE OF WISCONSIN INVESTMENT BOARD | 125,004 | $2,355 |
| Engineers Gate Manager LP | 120,354 | $2,267 |
| UBS Group AG | 120,031 | $2,261 |
| LAZARD ASSET MANAGEMENT LLC | 116,302 | $2,191 |
| Invesco Ltd. | 115,503 | $2,176 |
| FRANKLIN RESOURCES INC | 103,703 | $1,954 |
| TWO SIGMA ADVISERS, LP | 102,300 | $1,927 |
| Jump Financial, LLC | 100,956 | $1,902 |
| FORMULA GROWTH LTD | 100,668 | $1,897 |
| BALYASNY ASSET MANAGEMENT L.P. | 99,870 | $1,882 |
| MILLENNIUM MANAGEMENT LLC | 99,735 | $1,879 |
| Swiss National Bank | 99,700 | $1,878 |
| ARS Investment Partners, LLC | 94,339 | $1,777 |
| Rafferty Asset Management, LLC | 91,134 | $1,717 |
| TWO SIGMA INVESTMENTS, LP | 89,300 | $1,682 |
| AMERICAN CENTURY COMPANIES INC | 87,580 | $1,650 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 83,493 | $1,573 |
| Gotham Asset Management, LLC | 82,593 | $1,556 |
| GLOBEFLEX CAPITAL L P | 79,795 | $1,503 |
| Schonfeld Strategic Advisors LLC | 78,839 | $1,485 |
| PRINCIPAL FINANCIAL GROUP INC | 78,625 | $1,481 |
| ALGERT GLOBAL LLC | 70,150 | $1 |
| RHUMBLINE ADVISERS | 69,198 | $1,304 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 61,516 | $1,160 |
| WELLS FARGO & COMPANY/MN | 57,129 | $1,076 |
| PRUDENTIAL FINANCIAL INC | 55,495 | $1,046 |
| AMERIPRISE FINANCIAL INC | 52,549 | $990 |
| Aquatic Capital Management LLC | 52,076 | $981 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,545 | $896 |
| ALLIANCEBERNSTEIN L.P. | 46,460 | $875 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 46,388 | $874 |
| Palumbo Wealth Management LLC | 45,759 | $862 |
| DEUTSCHE BANK AG\ | 45,143 | $850 |
| EXCHANGE TRADED CONCEPTS, LLC | 43,590 | $821 |
| ACADIAN ASSET MANAGEMENT LLC | 40,607 | $1 |
| Virtus ETF Advisers LLC | 40,564 | $764 |
| JPMORGAN CHASE & CO | 39,508 | $744 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 39,218 | $1 |
| CANADA PENSION PLAN INVESTMENT BOARD | 38,600 | $727 |
| Squarepoint Ops LLC | 38,123 | $718 |
| PROFUND ADVISORS LLC | 33,867 | $638 |
| ExodusPoint Capital Management, LP | 31,240 | $589 |
| Creative Planning | 29,580 | $557 |
| MetLife Investment Management, LLC | 29,391 | $554 |
| 98 other institutions | 748,763 | $11,566 |