| ORBIMED ADVISORS LLC | 1,252,600 | $15,470 |
| JANUS HENDERSON GROUP PLC | 1,140,618 | $14,087 |
| BlackRock, Inc. | 427,474 | $5,279 |
| VANGUARD GROUP INC | 360,082 | $4,447 |
| TD Waterhouse Canada Inc. | 175,405 | $2,154 |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 175,000 | $2,161 |
| GEODE CAPITAL MANAGEMENT, LLC | 162,033 | $2,002 |
| Russell Investments Group, Ltd. | 160,238 | $1,979 |
| MILLENNIUM MANAGEMENT LLC | 128,970 | $1,593 |
| STATE STREET CORP | 68,941 | $851 |
| NORGES BANK | 65,000 | $803 |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 55,235 | $682 |
| NORTHERN TRUST CORP | 50,700 | $626 |
| Ghisallo Capital Management LLC | 50,000 | $618 |
| Burkehill Global Management, LP | 50,000 | $618 |
| SECTORAL ASSET MANAGEMENT INC | 47,700 | $589 |
| WESBANCO BANK INC | 37,000 | $457 |
| Boston Partners | 26,100 | $322 |
| Board of Trustees of The Leland Stanford Junior University | 25,030 | $309 |
| RENAISSANCE TECHNOLOGIES LLC | 24,300 | $300 |
| BANK OF AMERICA CORP /DE/ | 21,136 | $261 |
| COHEN & STEERS, INC. | 20,000 | $0 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,775 | $207 |
| Janney Montgomery Scott LLC | 15,800 | $0 |
| MERCER GLOBAL ADVISORS INC /ADV | 15,155 | $187 |
| GOLDMAN SACHS GROUP INC | 13,600 | $168 |
| MORGAN STANLEY | 13,329 | $165 |
| Bank of New York Mellon Corp | 13,104 | $162 |
| UBS Group AG | 10,686 | $132 |
| BARCLAYS PLC | 10,633 | $131 |
| DEUTSCHE BANK AG\ | 9,832 | $121 |
| WELLS FARGO & COMPANY/MN | 7,834 | $97 |
| RHUMBLINE ADVISERS | 4,419 | $55 |
| JPMORGAN CHASE & CO | 3,250 | $40 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,240 | $40 |
| BNP PARIBAS ARBITRAGE, SA | 2,150 | $27 |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,800 | $22 |
| Police & Firemen's Retirement System of New Jersey | 1,258 | $16 |
| STRS OHIO | 1,200 | $15 |
| Tower Research Capital LLC (TRC) | 1,032 | $13 |
| ROYAL BANK OF CANADA | 1,026 | $13 |
| iA Global Asset Management Inc. | 1,000 | $0 |
| Legal & General Group Plc | 657 | $8 |
| Ameritas Investment Partners, Inc. | 565 | $7 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 417 | $5 |
| JONES FINANCIAL COMPANIES LLLP | 380 | $5 |
| FMR LLC | 307 | $4 |
| AMALGAMATED BANK | 213 | $0 |
| CITIGROUP INC | 187 | $2 |
| Sterling Capital Management LLC | 179 | $2 |
| CWM, LLC | 167 | $0 |
| OSAIC HOLDINGS, INC. | 20 | $0 |
| EverSource Wealth Advisors, LLC | 5 | $0 |
| True Wealth Design, LLC | 4 | $0 |
| Allworth Financial LP | 2 | $0 |
| IFP Advisors, Inc | 2 | $0 |