CEMPRA INC

CUSIP: 15130J109 Class: COM

Opaleye Management Inc.'s Holding History (CIK: 0001595855)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 200,000 Value ($000) $6,226 Avg Close — Range —
Q3 2015
Shares 360,000 Value ($000) $10,022 Avg Close — Range —
Q2 2015
Shares 490,000 Value ($000) $16,836 Avg Close — Range —
Q1 2015
Shares 500,000 Value ($000) $17,155 Avg Close — Range —
Q4 2014
Shares 504,800 Value ($000) $11,868 Avg Close — Range —
Q3 2014
Shares 504,800 Value ($000) $5,532,608 Avg Close — Range —
Q2 2014
Shares 504,800 Value ($000) $5,417 Avg Close — Range —
Q1 2014
Shares 480,000 Value ($000) $5,544 Avg Close — Range —
Q4 2013
Shares 365,000 Value ($000) $4,745,000 Avg Close — Range —