| RA CAPITAL MANAGEMENT, L.P. | 3,365,523 | $743,410 |
| VANGUARD GROUP INC | 2,007,193 | $443,369 |
| BlackRock, Inc. | 1,680,662 | $371,241 |
| HBK INVESTMENTS L P | 1,260,000 | $278,321 |
| FIL Ltd | 1,257,574 | $277,786 |
| UBS Group AG | 1,074,924 | $237,440 |
| Darwin Global Management, Ltd. | 997,196 | $220,181 |
| Vivo Capital, LLC | 956,670 | $211,319 |
| STATE STREET CORP | 884,374 | $195,349 |
| Jefferies Financial Group Inc. | 766,520 | $169,317 |
| Paradigm Biocapital Advisors LP | 759,565 | $167,780 |
| BALYASNY ASSET MANAGEMENT L.P. | 672,890 | $148,635 |
| GLAZER CAPITAL, LLC | 650,191 | $144 |
| Pentwater Capital Management LP | 565,000 | $124,803 |
| MORGAN STANLEY | 542,722 | $119,882 |
| Beryl Capital Management LLC | 522,138 | $115,335 |
| GEODE CAPITAL MANAGEMENT, LLC | 520,591 | $115,018 |
| MILLENNIUM MANAGEMENT LLC | 509,647 | $112,576 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 477,527 | $105,481 |
| MAVERICK CAPITAL LTD | 455,978 | $100,721 |
| FARALLON CAPITAL MANAGEMENT LLC | 382,800 | $84,557 |
| GOLDMAN SACHS GROUP INC | 377,718 | $83,434 |
| Qube Research & Technologies Ltd | 358,432 | $79,174 |
| CITIGROUP INC | 348,421 | $76,963 |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AM | 315,474 | $69,685 |
| Logos Global Management LP | 310,000 | $68,476 |
| Squarepoint Ops LLC | 293,586 | $64,850 |
| NEXPOINT ASSET MANAGEMENT, L.P. | 279,900 | $61,827 |
| JPMORGAN CHASE & CO | 276,551 | $61,087 |
| SOROS FUND MANAGEMENT LLC | 275,000 | $60,745 |
| FMR LLC | 274,962 | $60,736 |
| Ikarian Capital, LLC | 273,243 | $60,357 |
| CITADEL ADVISORS LLC | 269,389 | $59,505 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 263,332 | $58,167 |
| Point72 Asset Management, L.P. | 250,000 | $55,223 |
| Magnetar Financial LLC | 232,537 | $51,365 |
| Spruce Street Capital LP | 232,269 | $51,306 |
| Weiss Asset Management LP | 224,998 | $49,700 |
| MARSHALL WACE, LLP | 222,763 | $49,206 |
| Polar Asset Management Partners Inc. | 216,998 | $47,933 |
| ALLIANCEBERNSTEIN L.P. | 212,028 | $46,835 |
| Verition Fund Management LLC | 210,329 | $46,460 |
| ALPINE ASSOCIATES MANAGEMENT INC. | 208,560 | $46,069 |
| BANK OF AMERICA CORP /DE/ | 207,844 | $45,911 |
| First Trust Capital Management L.P. | 205,233 | $45,334 |
| Rock Springs Capital Management LP | 204,878 | $45,256 |
| NORGES BANK | 200,000 | $44,178 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 190,700 | $42,124 |
| KRYGER CAPITAL Ltd | 185,313 | $40,934 |
| NEUBERGER BERMAN GROUP LLC | 184,873 | $40,837 |
| Sofinnova Investments, Inc. | 180,265 | $39,819 |
| NORTHERN TRUST CORP | 179,081 | $39,557 |
| PERCEPTIVE ADVISORS LLC | 165,131 | $36,476 |
| FRED ALGER MANAGEMENT, LLC | 164,575 | $36,353 |
| AQR Arbitrage LLC | 157,709 | $34,836 |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 155,631 | $34,377 |
| WATER ISLAND CAPITAL LLC | 150,708 | $33,290 |
| GABELLI FUNDS LLC | 148,666 | $32,839 |
| FNY Investment Advisers, LLC | 145,533 | $32 |
| ODDO BHF ASSET MANAGEMENT SAS | 142,500 | $31,477 |
| WHITEBOX ADVISORS LLC | 125,001 | $27,611 |
| Man Group plc | 116,713 | $25,781 |
| HIGHBRIDGE CAPITAL MANAGEMENT LLC | 112,980 | $24,956 |
| RENAISSANCE TECHNOLOGIES LLC | 110,560 | $24,422 |
| Velan Capital Investment Management LP | 108,404 | $23,945 |
| Octagon Capital Advisors LP | 100,000 | $22,089 |
| Eversept Partners, LP | 98,721 | $21,806 |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 95,805 | $21,162 |
| Walleye Capital LLC | 91,000 | $20,101 |
| ACUTA CAPITAL PARTNERS, LLC | 89,145 | $19,691 |
| BNP PARIBAS ARBITRAGE, SA | 86,869 | $19,188 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 85,098 | $18,797 |
| Sand Grove Capital Management LLP | 80,821 | $17,853 |
| BOOTHBAY FUND MANAGEMENT, LLC | 79,587 | $17,580 |
| BARCLAYS PLC | 78,322 | $17,301 |
| NAN FUNG TRINITY (HK) LTD | 77,100 | $17,031 |
| Slotnik Capital, LLC | 76,245 | $16,842 |
| PICTON MAHONEY ASSET MANAGEMENT | 75,000 | $16,567 |
| Versor Investments LP | 73,200 | $16,169 |
| Artia Global Partners LP | 70,824 | $15,644 |
| AMERIPRISE FINANCIAL INC | 68,986 | $15,238 |
| CAXTON ASSOCIATES LLP | 68,821 | $15,202 |
| Woodline Partners LP | 67,500 | $14,910 |
| AlphaCore Capital LLC | 66,790 | $14,753 |
| Governors Lane LP | 62,325 | $13,767 |
| ADAR1 Capital Management, LLC | 59,677 | $13,182 |
| FIRST TRUST ADVISORS LP | 59,551 | $13,154 |
| Public Sector Pension Investment Board | 58,844 | $12,998 |
| Bank of New York Mellon Corp | 58,553 | $12,934 |
| Sagefield Capital LP | 57,075 | $12,607 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 56,375 | $12,453 |
| LMR Partners LLP | 56,014 | $12,373 |
| Boxer Capital Management, LLC | 53,000 | $11,707 |
| HARVEST MANAGEMENT LLC | 52,500 | $11,597 |
| Burkehill Global Management, LP | 50,000 | $11,045 |
| Duquesne Family Office LLC | 49,495 | $11 |
| Chicago Capital Management, LLC | 49,000 | $8,173 |
| TUDOR INVESTMENT CORP ET AL | 44,307 | $9,787 |
| Nuveen, LLC | 43,127 | $9,526 |
| Birnam Oak Advisors, LP | 41,414 | $9,148 |
| 147 other institutions | 1,142,183 | $223,961 |