| RTW INVESTMENTS, LP | 8,757,390 | $60,426 |
| Deep Track Capital, LP | 7,334,323 | $50,607 |
| GMT CAPITAL CORP | 2,844,618 | $19,628 |
| TORONTO DOMINION BANK | 2,529,013 | $17,447 |
| ARK Investment Management LLC | 2,156,012 | $14,876 |
| UBS Group AG | 2,038,444 | $14,065 |
| TWO SIGMA INVESTMENTS, LP | 1,644,242 | $11,345 |
| Jefferies Financial Group Inc. | 1,576,905 | $10,881 |
| Eagle Health Investments LP | 1,519,388 | $10,484 |
| D. E. Shaw & Co., Inc. | 1,453,876 | $10,032 |
| MILLENNIUM MANAGEMENT LLC | 1,387,658 | $9,575 |
| Aisling Capital Management LP | 1,198,418 | $8,269 |
| MORGAN STANLEY | 1,137,520 | $7,849 |
| Siren, L.L.C. | 1,000,000 | $6,900 |
| RENAISSANCE TECHNOLOGIES LLC | 967,846 | $6,678 |
| Propel Bio Management, LLC | 861,778 | $5,946 |
| TWO SIGMA ADVISERS, LP | 856,500 | $5,910 |
| Point72 Asset Management, L.P. | 844,816 | $5,829 |
| Kalehua Capital Management LLC | 819,692 | $5,656 |
| DAFNA Capital Management LLC | 811,046 | $5,596 |
| PFM Health Sciences, LP | 779,618 | $5,379 |
| NEXTBio Capital Management LP | 752,631 | $5,193 |
| AMERIPRISE FINANCIAL INC | 645,065 | $4,451 |
| BlackRock, Inc. | 594,269 | $4,100 |
| CenterBook Partners LP | 578,828 | $3,994 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 570,462 | $3,834 |
| HighVista Strategies LLC | 498,933 | $3,443 |
| Blue Owl Capital Holdings LP | 469,914 | $3,242 |
| Nantahala Capital Management, LLC | 443,293 | $3,059 |
| Hennion & Walsh Asset Management, Inc. | 424,800 | $2,931 |
| Ikarian Capital, LLC | 400,000 | $2,760 |
| Squadron Capital Management LLC | 388,287 | $2,679 |
| JANE STREET GROUP, LLC | 336,728 | $2,323 |
| CITADEL ADVISORS LLC | 311,488 | $2,149 |
| Simplify Asset Management Inc. | 290,000 | $2,001 |
| BIT Capital GmbH | 288,814 | $1,993 |
| Founders Fund VII Management, LLC | 278,880 | $1,924 |
| Susquehanna Portfolio Strategies, LLC | 275,773 | $1,903 |
| Sumitomo Mitsui Trust Holdings, Inc. | 247,337 | $1,707 |
| Nikko Asset Management Americas, Inc. | 247,337 | $1,707 |
| AdvisorShares Investments LLC | 230,910 | $1,593 |
| Legal & General Group Plc | 218,406 | $1,507 |
| Brown University | 214,200 | $1,478 |
| Affinity Asset Advisors, LLC | 200,000 | $1,380 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,825 | $1,310 |
| ROYAL BANK OF CANADA | 181,168 | $1,250 |
| Y-Intercept (Hong Kong) Ltd | 174,258 | $1,202 |
| Jump Financial, LLC | 167,025 | $1,152 |
| STABLEFORD CAPITAL II LLC | 160,625 | $1,108 |
| Saba Capital Management, L.P. | 151,033 | $1,042 |
| BRIDGER MANAGEMENT, LLC | 147,209 | $1,016 |
| Bellevue Group AG | 142,243 | $981 |
| WELLS FARGO & COMPANY/MN | 139,937 | $966 |
| GOLDMAN SACHS GROUP INC | 126,980 | $876 |
| Palo Alto Investors LP | 115,616 | $798 |
| BOOTHBAY FUND MANAGEMENT, LLC | 111,088 | $767 |
| SIMPLEX TRADING, LLC | 105,230 | $726 |
| Parkman Healthcare Partners LLC | 99,472 | $686 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 85,136 | $587 |
| Engineers Gate Manager LP | 79,800 | $551 |
| STATE STREET CORP | 78,794 | $544 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 71,877 | $496 |
| GEODE CAPITAL MANAGEMENT, LLC | 62,962 | $434 |
| Intellectus Partners, LLC | 61,000 | $421 |
| FOX RUN MANAGEMENT, L.L.C. | 60,823 | $420 |
| Lion Point Capital, LP | 58,000 | $400 |
| XTX Topco Ltd | 56,786 | $392 |
| FLAX POND CAPITAL, LLC | 52,816 | $364 |
| FreeGulliver LLC | 45,000 | $311 |
| FLAGSHIP HARBOR ADVISORS, LLC | 42,599 | $294 |
| Seven Fleet Capital Management LP | 40,000 | $276 |
| Virtus Investment Advisers, LLC | 39,471 | $272 |
| Corient Private Wealth LLC | 38,438 | $265 |
| Graham Capital Management, L.P. | 36,144 | $249 |
| TUDOR INVESTMENT CORP ET AL | 34,720 | $240 |
| Schonfeld Strategic Advisors LLC | 33,533 | $231 |
| HighTower Advisors, LLC | 31,491 | $217 |
| Conservest Capital Advisors, Inc. | 25,363 | $175 |
| HRT FINANCIAL LP | 24,408 | $0 |
| GROUP ONE TRADING, L.P. | 23,529 | $162 |
| BANK OF AMERICA CORP /DE/ | 22,479 | $155 |
| STIFEL FINANCIAL CORP | 21,600 | $149 |
| Brooklyn Investment Group | 19,934 | $134 |
| Aquatic Capital Management LLC | 19,811 | $137 |
| Zhang Financial LLC | 19,037 | $131 |
| Squarepoint Ops LLC | 18,963 | $131 |
| Walleye Trading LLC | 16,409 | $113 |
| Scientech Research LLC | 15,982 | $110 |
| CWM, LLC | 15,530 | $0 |
| China Universal Asset Management Co., Ltd. | 15,353 | $106 |
| OLD NATIONAL BANCORP /IN/ | 15,265 | $105 |
| ACORN FINANCIAL ADVISORY SERVICES INC /ADV | 15,000 | $104 |
| U.S. Capital Wealth Advisors, LLC | 15,000 | $104 |
| Walleye Capital LLC | 14,976 | $103 |
| LGT Financial Advisors LLC | 14,700 | $101 |
| RAYMOND JAMES FINANCIAL INC | 14,531 | $100 |
| LPL Financial LLC | 13,946 | $96 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,855 | $96 |
| Ethos Financial Group, LLC | 13,532 | $93 |
| Magnetar Financial LLC | 13,194 | $91 |
| 67 other institutions | 120,464 | $801 |