CONSTELLATION PHARMCETICLS I

CUSIP: 210373106 Class: COM

SPHERA FUNDS MANAGEMENT LTD.'s Holding History (CIK: 0001496201)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 40,162 Value ($000) $544 Avg Close — Range —
Q4 2018
Shares 70,162 Value ($000) $281 Avg Close — Range —