CONTINEUM THERAPEUTICS INC

Ticker: CTNM CUSIP: 21217B100 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 37,916 Value ($000) $433 Avg Close $11.41 Range $10.07 - $13.48

Q3 2025

Shares 37,943 Value ($000) $446 Avg Close $8.06 Range $3.72 - $13.49

Q2 2025

Shares 60,963 Value ($000) $242 Avg Close $4.35 Range $3.35 - $6.97

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	37,916	$433	$11.41	$10.07 - $13.48
Q3 2025	37,943	$446	$8.06	$3.72 - $13.49
Q2 2025	60,963	$242	$4.35	$3.35 - $6.97