| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,841,334 | $32,476 |
| JANUS HENDERSON GROUP PLC | 2,448,979 | $27,906 |
| RA CAPITAL MANAGEMENT, L.P. | 2,179,711 | $24,914 |
| JOHNSON & JOHNSON | 1,979,173 | $22,622 |
| FRANKLIN RESOURCES INC | 1,879,367 | $21,481 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,842,800 | $21,063 |
| PERCEPTIVE ADVISORS LLC | 1,464,592 | $16,740 |
| BAKER BROS. ADVISORS LP | 1,420,838 | $16,240 |
| VANGUARD GROUP INC | 1,270,858 | $14,526 |
| MILLENNIUM MANAGEMENT LLC | 830,687 | $9,495 |
| Commodore Capital LP | 816,326 | $9,331 |
| FMR LLC | 814,871 | $9,314 |
| SECTORAL ASSET MANAGEMENT INC | 800,787 | $9,153 |
| GREAT POINT PARTNERS LLC | 800,000 | $9,144 |
| Point72 Asset Management, L.P. | 759,227 | $8,678 |
| HHLR ADVISORS, LTD. | 669,337 | $7,651 |
| RED TREE MANAGEMENT, LLC | 638,158 | $7,294 |
| Versant Venture Management, LLC | 542,628 | $6,202 |
| BlackRock, Inc. | 536,155 | $6,128 |
| Boxer Capital Management, LLC | 494,000 | $5,646 |
| Longaeva Partners L.P. | 470,000 | $5,372 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 307,540 | $3,515 |
| Ikarian Capital, LLC | 282,874 | $3,233 |
| ADAR1 Capital Management, LLC | 278,961 | $3,189 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 265,761 | $3,038 |
| GEODE CAPITAL MANAGEMENT, LLC | 213,869 | $2,446 |
| AMERIPRISE FINANCIAL INC | 209,633 | $2,396 |
| UBS Group AG | 199,389 | $2,279 |
| MARSHALL WACE, LLP | 180,804 | $2,067 |
| SPHERA FUNDS MANAGEMENT LTD. | 173,475 | $1,983 |
| Casdin Capital, LLC | 148,333 | $1,695 |
| Eversept Partners, LP | 137,493 | $1,572 |
| Monashee Investment Management LLC | 137,430 | $1,571 |
| MORGAN STANLEY | 124,286 | $1,421 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,061 | $1,258 |
| GOLDMAN SACHS GROUP INC | 105,594 | $1,207 |
| 683 Capital Management, LLC | 91,442 | $1,045 |
| STATE STREET CORP | 84,428 | $965 |
| BOOTHBAY FUND MANAGEMENT, LLC | 72,494 | $829 |
| Samsara BioCapital, LLC | 72,245 | $826 |
| ACADIAN ASSET MANAGEMENT LLC | 64,705 | $1 |
| BNP PARIBAS ARBITRAGE, SA | 64,228 | $734 |
| BARCLAYS PLC | 59,507 | $680 |
| Trexquant Investment LP | 59,031 | $675 |
| RENAISSANCE TECHNOLOGIES LLC | 57,100 | $653 |
| NORTHERN TRUST CORP | 53,876 | $616 |
| ExodusPoint Capital Management, LP | 51,028 | $583 |
| Strategies Wealth Advisors, LLC | 50,000 | $572 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 49,280 | $563 |
| Qube Research & Technologies Ltd | 43,078 | $492 |
| TWO SIGMA INVESTMENTS, LP | 37,916 | $433 |
| OMERS ADMINISTRATION Corp | 34,900 | $399 |
| JANE STREET GROUP, LLC | 27,945 | $319 |
| Hudson Bay Capital Management LP | 25,938 | $296 |
| Quadrature Capital Ltd | 23,377 | $267 |
| Schonfeld Strategic Advisors LLC | 22,673 | $259 |
| RBF Capital, LLC | 20,000 | $229 |
| AMERICAN CENTURY COMPANIES INC | 19,522 | $223 |
| Brevan Howard Capital Management LP | 19,426 | $222 |
| Graham Capital Management, L.P. | 17,074 | $195 |
| OCCUDO QUANTITATIVE STRATEGIES LP | 15,036 | $172 |
| Persistent Asset Partners Ltd | 13,853 | $158 |
| CITIGROUP INC | 12,324 | $141 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,300 | $0 |
| BANK OF AMERICA CORP /DE/ | 9,269 | $106 |
| China Universal Asset Management Co., Ltd. | 3,764 | $43 |
| ROYAL BANK OF CANADA | 3,340 | $38 |
| Federation des caisses Desjardins du Quebec | 2,560 | $29 |
| JPMORGAN CHASE & CO | 1,792 | $20 |
| Torren Management, LLC | 1,562 | $18 |
| CWM, LLC | 1,180 | $0 |
| Mirae Asset Global Investments Co., Ltd. | 1,122 | $13 |
| GF FUND MANAGEMENT CO. LTD. | 454 | $5 |
| Fortitude Family Office, LLC | 445 | $5 |
| Banque Transatlantique SA | 220 | $3 |
| Tower Research Capital LLC (TRC) | 124 | $1 |
| Optiver Holding B.V. | 104 | $1 |
| GROUP ONE TRADING, L.P. | 103 | $1 |
| Cornerstone Financial Management LLC | 64 | $1 |