CYCLERION THERAPEUTICS INC

Ticker: CYCN CUSIP: 23255M204 Class: COM

Holders for Q4 2025 Position Changes for Q4 2025

Note: Option positions (PUT/CALL) are excluded.

New Positions (3)

TWO SIGMA ADVISERS, LP

Value ($000) $36 Shares 28,300

Value ($000) $13 Shares 10,027

Value ($000) $10 Shares 8,204

Institution	Shares	Value ($000)
TWO SIGMA ADVISERS, LP	28,300	$36
XTX Topco Ltd	10,027	$13
CITIGROUP INC	8,204	$10

Increased Positions (5)

TWO SIGMA INVESTMENTS, LP

Value ($000) $53 (+72.6%) Shares 41,555 (+212.6%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $55 (-35.7%) Shares 43,302 (+16.5%)

Tower Research Capital LLC (TRC)

Value ($000) $4 (-25.2%) Shares 3,154 (+35.5%)

Value ($000) $0 (+323.0%) Shares 376 (+667.3%)

BANK OF AMERICA CORP /DE/

Value ($000) $0 (+172.0%) Shares 107 (+386.4%)

Institution	Prev Shares	Curr Shares	Change
TWO SIGMA INVESTMENTS, LP	13,293	41,555	+28,262 (+212.6%)
GEODE CAPITAL MANAGEMENT, LLC	37,158	43,302	+6,144 (+16.5%)
Tower Research Capital LLC (TRC)	2,328	3,154	+826 (+35.5%)
UBS Group AG	49	376	+327 (+667.3%)
BANK OF AMERICA CORP /DE/	22	107	+85 (+386.4%)

Decreased Positions (1)

Value ($000) $0 (-99.9%) Shares 1 (-99.8%)

Institution	Prev Shares	Curr Shares	Change
MORGAN STANLEY	649	1	-648 (-99.8%)

Exited Positions (1)

DRW Securities, LLC

Value ($000) $100 Shares 43,617

Institution	Prev Shares	Prev Value ($000)
DRW Securities, LLC	43,617	$100